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Growth hormone responses to L-dopa in depressed patients.

Authors
Sachar-EJ; Mushrush-G; Perlow-M; Weitzman-ED; Sassin-J
Source
Science 1972 Dec; 178(4067):1304-1305
NIOSHTIC No.
00038654
Abstract
Plasma human growth hormone responses to oral administration of 500 milligrams of L-dopa (59927) are analyzed in three groups of subjects: normals age 20-32; normals age 48-68; and unipolar depressed patients, age 45 to 68. While only 7 percent of the young normals have deficient human growth hormone responses to this stimulus, 36 percent of the older normals and 77 percent of the depressed patients fail to have adequate responses, suggesting an effect of age and a further effect of depressive illness. Because the release of human growth hormone appears to be closely related to brain catecholamine metabolism, the deficient responses in the depressed patients may provide further support to the concept of a neurochemical defect in depressive illness.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Amines; Drugs; Hormone-metabolism
Contact
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
CODEN
SCIEAS
CAS No.
59-92-7
Publication Date
19721222
Document Type
Journal Article
Funding Amount
346110.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00331
Issue of Publication
4067
ISSN
0036-8075
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Science
State
NY
Performing Organization
Montefiore Hospital and Medical Center, New York, New York
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