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The effect of lung reactive antibodies on the pathogenesis of tuberculosis.

Authors
Burrell-R; Cate-CC
Source
Clin Exp Immunol 1971 Dec; 9(6):809-819
NIOSHTIC No.
00038653
Abstract
Injections of washed mouse lung-CCT suspended in Freund's complete adjuvant are given to mice and guinea-pigs to stimulate production of homologous and heterologous mouse lung-reactive antibodies harvested as peritoneal ascitic fluid and serum, respectively. Reactivity of the homologous antibody is limited to relatively weak, but lung-specific, focal localization in the alveolar septa of recipient mice as demonstrated by immunofluorescence studies. An index of tuberculous involvement is developed that correlates the enhanced spread of tubercle bacilli with administration of heterologous immune serum and allowed quantitation of the immune response as a function of histopathology. The effect of heterologous immune serum on experimental tuberculosis infection is an alteration in the appearance of and an increase in the number of lesions resembling a miliary spread of the organisms not seen in the controls.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Lung-disorders; Antigens; Respiratory-system-disorders; Infectious-diseases
Contact
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
CODEN
CEXIAL
Publication Date
19711201
Document Type
Journal Article
Funding Amount
289015
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00360
Issue of Publication
6
ISSN
0009-9104
Priority Area
Pulmonary-system-disorders
Source Name
Clinical and Experimental Immunology
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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