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Prostaglandin regulation of airway smooth muscle tone.

Authors
Orehek-J; Douglas-JS; Lewis-AJ; Bouhuys-A
Source
Nature, New Biology 1973 Sep; 245(142):84-85
NIOSHTIC No.
00036329
Abstract
In-vitro experiments indicate that the tone of the isolated guinea- pig trachea is modulated by the prostaglandins released subsequent to injection of histamine (51456) and acetylcholine (51843), if the prostaglandins (11000263) reach the airway smooth muscle. To prevent prostaglandin interference when assessing the effects of contractile agents, the tracheal strips required treatment with prostaglandin synthesis inhibitors, including aspirin (50782) and indomethacin (53861).
Keywords
NIOSH-Publication; NIOSH-Grant; Respiratory-functions; Muscle-functions; Muscle-tone; Respiratory-system; Muscle-relaxants; Muscle-contractions; Pharmacology; Drugs; Analgesics
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
NNBYA7
CAS No.
51-45-6; 51-84-3; 11000-26-3; 50-78-2; 53-86-1
Publication Date
19730919
Document Type
Journal Article;
Funding Amount
513539
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
142
ISSN
0369-4887
Source Name
Nature, New Biology
State
CT
Performing Organization
John B. Pierce Foundation of Connecticut Inc, New Haven, Connecticut,
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