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Neurotoxicity produced by intracranial administration of methylmercury in rats.

Authors
Richardson-RJ; Murphy-SD
Source
Toxicol Appl Pharmacol 1974 Aug; 29(2):289-300
NIOSHTIC No.
00036323
Abstract
Methylmercuric-chloride (115093) administered as a single intracranial injection in microgram quantities produced a neurological syndrome in rats within 24 hours that resembled the effects produced by repeated subcutaneous injection of 10 milligrams per kilogram over a period of 7-14 days. Neuromuscular function evaluated semiquantitatively by graded performance in simple strength and coordination tests showed severe impairment at 24 hours in intracranially methylmercury-treated animals, with recovery taking place by 72 hours. Body weight decreased and recovered during a similar time course. Incorporation of tritiated leucine into brain protein was increased significantly at 24 hours as measured in vitro in and in vivo. Incorporation returned to control values by 72 hours after the methylmercury injection. Residual brain mercury (7439976) concentrations at 24 hours were about 5-fold lower than those accompanying overt neurological signs in rats produced by subcutaneous administration. Histological examination of brains from intracranially and subcutaneously dosed rats revealed that the lesions produced by the 2 methods were substantially different. Intracranial injection of methylmercury was found to produce an isolated neurotoxic syndrome similar in some respects to the neurotoxicity seen in systemic intoxications but dissimilar histopathologically.
Keywords
NIOSH-Publication; NIOSH-Grant; Toxicology; Mercury-poisoning; Metal-poisoning; Organo-mercury-compounds; Nervous-system-disorders; Time-dose-relationship; Neuromuscular-system-disorders; Histopathology; Radioactive-tracer-analysis; Brain-disorders; Test-methods
Contact
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
CODEN
TXAPA9
CAS No.
115-09-3; 7439-97-6
Publication Date
19740801
Document Type
Journal Article
Funding Amount
274679
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00315
Issue of Publication
2
ISSN
0041-008X
Source Name
Toxicology and Applied Pharmacology
State
MA
Performing Organization
Harvard University, Boston, Massachusetts
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