Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

In vitro histamine release from human lung as a model for the acute response to cotton dust.

Authors
Hitchcock-M
Source
Ann NY Acad Sci 1974 Feb; 221(1):124-131
NIOSHTIC No.
00036311
Abstract
An in vitro system for the acute response in byssinosis due to cotton dust confirms the conclusion from in vivo observations that the dust contains a pharmacological agent capable of releasing histamine, with data suggesting that the same mechanism is responsible for histamine (51456) release and bronchoconstriction. Methyl piperonylate is suggested as the cotton bract component responsible. The presence of a pharmacological agent in cotton dust does not explain the etiology of chronic byssinosis, since reversible bronchoconstriction follows exposure to dust by healthy workers without byssinosis. However, epidemiological studies show that persons who respond acutely to cotton dust are likely to develop chronic byssinosis. Thus the acute reversible bronchoconstriction in response to cotton dust may be useful in predicting individual susceptibility to chronic byssinosis.
Keywords
NIOSH-Publication; NIOSH-Grant; Respiratory-system-disorders; Respiratory-mechanics; Allergic-reactions; Sensitization; Biochemical-reactions
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
ANYAA9
CAS No.
51-45-6
Publication Date
19740228
Document Type
Journal Article
Funding Amount
513539
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
1
ISSN
0077-8923
Priority Area
Respiratory-system-disorders
Source Name
Annals of the New York Academy of Sciences
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
TOP