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Delta-aminolevulinate dehydratase, a zinc dependent enzyme.

Authors
Finelli-VN; Murthy-L; Peirano-WB; Petering-HG
Source
Biochem Biophys Res Commun 1974 Jan; 60(4):1418-1424
NIOSHTIC No.
00036303
Abstract
Erythrocyte and liver tissue delta-aminolevulinate dehydratase activity is determined in rats fed a semipurified diet under controlled nutritional intake of zinc (7440666) and copper (7440508). A significant decrease in enzymatic activity is observed in animals fed a low zinc diet, while dietary copper has no effect. In vitro addition of zinc to the erythrocyte preparations obtained from rats on low zinc diet produces a slight increase in enzymatic activity. Though zinc is the metal ion activator of the enzyme, the requirement of zinc is at the site of enzyme synthesis.
Keywords
NIOSH-Publication; NIOSH-Grant; Enzyme-activity; Metallic-ions; Heavy-metals
Contact
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
CODEN
BBRCA9
CAS No.
7440-66-6; 7440-50-8
Publication Date
19740101
Document Type
Journal Article
Funding Amount
311966
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00337
Issue of Publication
4
ISSN
0006-291X
Source Name
Biochemical and Biophysical Research Communications
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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