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The effect of sodium hydroxide and hydrochloric acid on human epidermis.

Authors
Nagao-S; Stroud-JS; Hamada-T; Pinkus-H; Birmingham-DJ
Source
Acta Derm Venereol 1972 Jan; 52(1):11-23
NIOSHTIC No.
00033510
Abstract
Electron microscopy of biopsy epidermis specimens obtained from the human forearm following the application of normal sodium-hydroxide (1310732) or normal hydrochloric-acid (7647010) reveals cellular and structural differences characteristic for each compound. Both treatments produce intracellular edema, the shortest time associated with recognizable changes in noncornified cells being 15 minutes with sodium-hydroxide and 120 minutes with hydrochloric-acid. The results establish a baseline for comparison with other concentrations of acid and base, and a variety of other agents, and can provide a better understanding of structural changes found in contact dermatitis.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Electron-optics; Skin-disorders; Inorganic-acids; Allergic-reactions; Morphology; Cytopathology; Cytology; Histopathology; Alkalies
Contact
Dermatology Wayne State University 540 East Canfield Street Detroit, Mich 48201
CODEN
ADVEA4
CAS No.
1310-73-2; 7647-01-0
Publication Date
19720101
Document Type
Journal Article
Funding Amount
128001
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-000410
Issue of Publication
1
ISSN
0001-5555
Priority Area
Dermatitis
Source Name
Acta Dermato-Venereologica
State
MI
Performing Organization
Wayne State University, Detroit, Michigan
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