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An electron microscopic study of human epidermis after acetone and kerosene administration.

Authors
Lupulescu-AP; Birmingham-DJ; Pinkus-H
Source
J Invest Dermatol 1973 Jan; 60(1):33-45
NIOSHTIC No.
00033509
Abstract
Electron microscopy reveals that exposure of human skin to acetone (67641) results in marked intracellular edema of keratinized cells and vacuolation of spinous cells, while kerosene induces large lacunae and disappearance of the keratin pattern in keratinized cells, and cytolysis of spinous cells. The cytoplasmic and nuclear degenerative changes are more pronounced after 90 minutes than following 30 minute exposure. A high degree of restoration of the normal ultrastructural pattern occurs at 72 hours after discontinuing exposure.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Organic-solvents; Cytopathology; Subcellular-structure; Skin-disorders; Cytology; Electron-optics; Fuels; Histopathology; Dermatology; Ketones
Contact
Dermatology Wayne State University 540 East Canfield Street Detroit, Mich 48201
CODEN
JIDEAE
CAS No.
67-64-1
Publication Date
19730101
Document Type
Journal Article
Funding Amount
128001
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-000410
Issue of Publication
1
ISSN
0022-202X
Priority Area
Dermatitis
Source Name
Journal of Investigative Dermatology
State
MI
Performing Organization
Wayne State University, Detroit, Michigan
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