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Morphologic and ultrastructural changes in the lungs of animals during acute exposure to ozone.

Authors
Boatman-ES; Frank-R
Source
Chest 1974 Apr; 65(4):9-11
NIOSHTIC No.
00028102
Abstract
Light microscopy, scanning electron microscopy, and transmission electron microscopy studies are made of the morphologic and ultrastructural changes occurring in the respiratory system of cats and rabbits exposed to low concentrations of ozone. Considerable desquamation is produced by ozone in airway lining cells, the degree of damage being proportional to the concentration (0.25, 0.5, and 1.0 ppm for 3 to 4.5 hours). Ciliated cells sustain more damage than goblet cells, mucus secreting cells or cuboidal cells, and many ciliated cells are found free in the airway luminae, desquamation frequently exposing the underlying basal cells and the basement membrane of the lamina propria.
Keywords
NIOSH-Publication; NIOSH-Grant; Toxic-gases; Respiratory-system-disorders; Irritants; Histopathology; Cytopathology; Acute-intoxication; Diagnostic-methods; Mitochondria; Lung
Contact
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
CODEN
CHETBF
CAS No.
10028-15-6
Publication Date
19740401
Document Type
Journal Article
Funding Amount
420211
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00340
Issue of Publication
4
ISSN
0012-3692
Source Name
Chest
State
WA
Performing Organization
University of Washington, Seattle, Washington
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