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Hepatic disease among workers at a vinyl chloride polymerization plant.

Authors
Falk-HJ Jr.; Heath-CW Jr.; Johnson-MN; Key-MM
Source
JAMA J Am Med Assoc 1974 Jan; 230(1):59-63
NIOSHTIC No.
00027189
Abstract
Eleven cases of hepatic disease including angiosarcoma are identified among men employed at a vinyl chloride polymerization plant through systematic medical screening. Ages at diagnosis range from 36 to 58 years for seven patients with liver angiosarcoma and from 28 to 56 years for four patients with nonmalignant disease; durations of employment before diagnosis from 12 to 28 years and from 5 to 29 years. All 11 persons have worked in close and continuous contact with various phases of the vinyl chloride polymerization process in polyvinylchloride production. Review of pathologic material suggests the presence in both tumor and nontumor cases of portal fibrosis and atypical sinusoidal lining cells. A direct causal relationship is postulated between exposure to vinyl chloride monomer and pathologic findings.
Keywords
NIOSH-Author; Liver-disorders; Liver-cancer; Chlorinated-hydrocarbons; Chemical-carcinogens; Rubber-industry; Chemical-manufacturing-industry; Histopathology; Liver-fibrosis; Vinyl-resins
CODEN
JAMAAP
CAS No.
75-01-4
Publication Date
19740107
Document Type
Journal Article
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0098-7484
Source Name
Journal of the American Medical Association
State
GA; KY; MD
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