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Chronic animal inhalation toxicity to cobalt.

Authors
Kerfoot-EJ
Source
NIOSH 1973 Jan; :1-37
Link
NIOSHTIC No.
00024938
Abstract
The toxic effects of chronic exposure of swine by inhalation to 0.1 milligrams (present threshold limit value for workers) and 1.0 milligram of cobalt (7440484) metal powder per cubic meter of air for six hours at five days per week for three months are studied by pulmonary function tests, electrocardiograms, x-ray examinations, blood tests, skin tests, urinalysis, and electron microscopy and light microscopy examination of tissue. Observed phenomena include decrease in lung compliance and other pulmonary parameters, cardiovascular changes indicating functional abnormalities, and collagenization or increased amount of septal collagen in the lungs. The present threshold limit value for cobalt is judged to be inadequate for protection of workers.
Keywords
NIOSH-Contract; NIOSH-Author; Contract-099-71-0019; Toxic-substances; Respiratory-system-disorders; Cardiovascular-system-disorders; Histopathology; Blood-chemistry; Heavy-metals; Air-contaminants; Hazardous-materials; Toxicology; Fibrosis
CAS No.
7440-48-4;
Publication Date
19730101
Document Type
Numbered Publication
Funding Type
Contract
Fiscal Year
1973
NTIS Accession No.
PB-232247
NTIS Price
A04
Identifying No.
(NIOSH) 74-115; TR-203-74; Contract-099-71-0019
NIOSH Division
DLCD
Source Name
National Institute for Occupational Safety and Health
State
OH
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