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Are trace metals associated with asbestos fibers responsible for the biologic effects attributed to asbestos?

Authors
Cralley-LJ; Lainhart-WS
Source
J Occup Med 1973 Mar; 15(3):262-266
NIOSHTIC No.
00023959
Abstract
The role of trace metals associated with asbestos (1332214) in relation to the biologic response to asbestos is evaluated by reviewing the predominant biologic responses to asbestos and the pathogenic mechanisms involved, identifying the trace metals associated with different types of asbestos, and presenting evidence relating the response to the presence of trace metals. Data are given for the comparative levels of nickel (7440020), chromium (7440473), cobalt (7440484), and manganese (7439965) in different size factors of mine milled chrysotile (12001295), crocidolite (12001284), amosite (12172735), and anthophyllite (17068789), and also for tumors observed at site of injection after 17 months in rats. Results do not indicate any definitive evidence that relates the fibrogenic properties of asbestos fibers or their potential to form asbestos bodies to trace metals associated with the fibers, but suggest that the electromotive interactions of the metals and minerals present are important determinants in the carcinogenic action of asbestos.
Keywords
JOCMA7; NIOSH-Author; Mineral-dusts; Respiratory-system-disorders; Lung-cancer; Metal-poisoning; Carcinogens; Respirable-dusts; Trace-elements; Physiological-effects; Metallic-dusts; Fibrous-dusts; Reactive-dusts
CODEN
JOCMA7
CAS No.
1332-21-4; 7440-02-0; 7440-47-3; 7440-48-4; 7439-96-5; 12001-29-5; 12001-28-4; 12172-73-5; 17068-78-9
Publication Date
19730301
Document Type
Journal Article
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0096-1736
Priority Area
Respiratory-system-disorders
Source Name
Journal of Occupational Medicine
State
OH
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