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Inhibition of histamine-induced airway constriction by ascorbic acid.

Authors
Zuskin-E; Lewis-AJ; Bouhuys-A
Source
J Allergy Clin Immunol 1973 Apr; 51(4):218-226
NIOSHTIC No.
00023895
Abstract
The effect of ascorbic-acid (50817) on histamine induced airway constriction is studied in 17 human subjects, and on guinea-pig tracheal strips in-vitro. Ventilatory function was measured by recording partial expiratory flow volume (PEFV) curves on which maximum flow rates at 50% and 25% vital capacity are calculated following oral administration of 500 milligrams of ascorbic-acid, the mean reductions of ventilatory capacity being significantly smaller in comparison with placebo administration (P less than contractions induced by histamine and relaxes the tissue in the absence of other agents. Propranolol does not block the effect of ascorbic-acid in man (80 milligrams orally), but in-vitro relaxations of tracheal strips by ascorbic-acid are reduced by 2.5 micrograms of propranolol (525666). Ascorbic-acid probably has a direct effect on airway smooth muscle; in the guinea pig trachea, the effect may be mediated by beta-adrenergic receptors.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Adrenergic-blocking-agents; Antihistamines; Airway-obstruction; Pulmonary-function-tests; Sensitizers; Pharmacology; Muscle-contractions; Therapeutic-agents; Aerosols; Bronchial-asthma
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
JACIBY
CAS No.
50-81-7; 525-66-6
Publication Date
19730401
Document Type
Journal Article
Funding Amount
513539.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
4
ISSN
0091-6749
Priority Area
Pulmonary-system-disorders
Source Name
Journal of Allergy and Clinical Immunology
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
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