Inhibition of histamine-induced airway constriction by ascorbic acid.
Zuskin-E; Lewis-AJ; Bouhuys-A
J Allergy Clin Immunol 1973 Apr; 51(4):218-226
The effect of ascorbic-acid (50817) on histamine induced airway constriction is studied in 17 human subjects, and on guinea-pig tracheal strips in-vitro. Ventilatory function was measured by recording partial expiratory flow volume (PEFV) curves on which maximum flow rates at 50% and 25% vital capacity are calculated following oral administration of 500 milligrams of ascorbic-acid, the mean reductions of ventilatory capacity being significantly smaller in comparison with placebo administration (P less than contractions induced by histamine and relaxes the tissue in the absence of other agents. Propranolol does not block the effect of ascorbic-acid in man (80 milligrams orally), but in-vitro relaxations of tracheal strips by ascorbic-acid are reduced by 2.5 micrograms of propranolol (525666). Ascorbic-acid probably has a direct effect on airway smooth muscle; in the guinea pig trachea, the effect may be mediated by beta-adrenergic receptors.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Adrenergic-blocking-agents; Antihistamines; Airway-obstruction; Pulmonary-function-tests; Sensitizers; Pharmacology; Muscle-contractions; Therapeutic-agents; Aerosols; Bronchial-asthma
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Journal of Allergy and Clinical Immunology
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