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Airway dilatation and constriction in spontaneously breathing guinea pigs.

Authors
Douglas-JS; Dennis-MW; Ridgway-P; Bouhuys-A
Source
J Pharmacol Exp Ther 1972; 180(1):98-189
NIOSHTIC No.
00023894
Abstract
Breath by breath recordings of tidal volume, air flow and pleural pressure, with on-line analog computation of dynamic lung compliance and pulmonary resistance, allow the quantitative assessment of actions of drugs on airways of guinea pigs under nearly physiological conditions. Isoproterenol reduces resistance but has little effect on compliance unless given to animals with induced airway constriction. Histamine usually reduces compliance more than it increases resistance and the compliance changes are dose-related. The experiments with inulin allow an estimate of the amounts of aerosolized drugs delivered to the airways. Aerosols appear to be a more efficient vehicle for the delivery of drugs to airways than solutions infused intravenously. Anesthesia reduces the guinea pig's sensitivity to histamine. Individual variations in the response to histamine among unanesthetized animals probably reflect differences in airway smooth muscle sensitivity to the drug.
Keywords
NIOSH-Publication; NIOSH-Grant; Airway-obstruction; Pulmonary-function-tests; Physiological-responses; Sensitizers; Muscle-contractions; Statistical-analysis; Mechanical-properties; Plethysmographs; PM9005805
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
JPETAB
CAS No.
51-31-0; 51-45-6
Publication Date
19720101
Document Type
Journal Article
Funding Amount
513539.00
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
1
ISSN
0022-3565
Source Name
Journal of Pharmacology and Experimental Therapeutics
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
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