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Selective and non-selective histamine release from rat, guinea-pig, and human lung.

Authors
Hitchcock-M
Source
Comp Gen Pharmacol 1973 Mar; 4(13):81-90
NIOSHTIC No.
00023893
Abstract
The lungs of rats, guinea-pigs, and humans are compared for total histamine content, histamine release by compound 48/80 and Triton-X- 100, and histamine metabolism. Total lung histamine decreases in the following order: guinea-pig, human, rat. Under the experimental conditions used, the amount of histamine released by compound 48/80 decreases as follows: human, rat, guinea-pig. Both rat and guinea- pig metabolize added histamine, the former mainly via diamine oxidase, the latter by some other metabolic system and human lung does not metabolize added histamine. With guinea-pig and human lung, histamine release by compound 48/80 is found to be selective, since it is not accompanied by release of intracellular constituents such as lactic dehydrogenase, protein, and histamine metabolizing enzymes. With rat lung, compound 48/80 causes some nonselective histamine release. In the lungs of all three species, Triton-X-100 causes nonselective release of histamine.
Keywords
NIOSH-Grant; Cytology; Allergenic-effects; Enzyme-inhibitors; Cellular-function; Stimulation; Enzyme-activity; Biochemistry; Author Keywords: Rats; guinea-pigs; humans; lung; histamine; compound 48/80; Triton-X-100; selective release; non-selective release; metabolism; lactic dehydrogenase
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
CPGPAY
Publication Date
19730301
Document Type
Journal Article
Funding Amount
513539
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
ISSN
0010-4035
Source Name
Comparative and General Pharmacology
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
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