Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Airway constriction in guinea pigs: interaction of histamine and autonomic drugs.

Authors
Douglas-JS; Dennis-MW; Ridgway-P; Bouhuys-A
Source
J Pharmacol Exp Ther 1973 Jan; 184(1):169-179
NIOSHTIC No.
00023857
Abstract
Dose-response curves to intravenous or aerosolized histamine were prepared in 131 guinea pigs using changes of dynamic lung compliance as a measure of response. The median effective dose values to aerosolized histamine varied according to a log normal distribution. Histamine responses were modified with various autonomic drugs. The results suggest that autonomic mediators interact with histamine in its effect on airway smooth muscle. The individual variability of histamine sensitivity may depend, in part, on the balance between cholinergic and beta adrenergic stimuli which impinge on airway smooth muscle.
Keywords
NIOSH-Publication; NIOSH-Grant; Respiratory-mechanics; Physiological-responses; Statistical-analysis; Bronchoconstriction; Intracellular-alterations; Respiratory-functions; Nervous-system-functions; Respiratory-distress
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
JPETAB
CAS No.
51-45-6
Publication Date
19730101
Document Type
Journal Article
Funding Amount
513539.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
1
ISSN
0022-3565
Source Name
Journal of Pharmacology and Experimental Therapeutics
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
TOP