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Adenosine 3',5'-cyclic monophosphate phosphodiesterase in guinea-pig lung—Properties and effect of adrenergic drugs.

Authors
Hitchcock-M
Source
Biochem Pharmacol 1973; 22(8):959-969
NIOSHTIC No.
00023855
Abstract
The hydrolysis of adenosine-3',5'-cyclic-monophosphate (60924) (cAMP) by adenosine-3',5'-monophosphate-phosphodiesterase (PDE) was studied in whole homogenates and cell fractions of guinea-pig lung. cAMP has been implicated as a controlling agent in a number of processes which govern lung function. Increases in cAMP have been associated with tracheal smooth muscle relaxation and decreases with the immunological release of histamine (51456) from human lung. The physiological responses of these systems and the intracellular cAMP levels respond to stimulation with isoproterenol, epinephrine, norepinephrine (51412), and methoxamine (390283) via both alpha and beta receptors. This report describes the results of experiments which demonstrated that guinea-pig lung contains two forms of phosphodiesterase with different affinities for cAMP and that predominately the low affinity form is affected by adrenergic drugs.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Catecholamines; Sympathetic-nervous-system; Enzyme-activity; Cytology; Histamine; Endocrinology; Sympathomimetics; Biochemistry; Pulmonary-system; Pharmacology
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
BCPCA6
CAS No.
60-92-4; 51-45-6; 51-41-2; 390-28-3
Publication Date
19730101
Document Type
Journal Article
Funding Amount
513539.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
8
ISSN
0006-2952
Priority Area
Pulmonary-system-disorders; Pulmonary-system
Source Name
Biochemical Pharmacology
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
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