Histamine release from human lung by a component of cotton bracts.
Hitchcock-M; Piscitelli-DM; Bouhuys-A
Arch Environ Health 1973 Apr; 26(4):177-182
Studies to determine the localization of the histamine-releasing agent in the cotton plant revealed that only the bracts extract contained significant activity. No histamine could be detected following incubation of lung tissue with extracts of pericarps or fibers. Detectable amounts of histamine were released by the bracts extract in eight of 17 trials. The individual variation in the amount of histamine released by compound 48/80 was also wide and varied from 11.9% to 55.4% of the total histamine present. A steam volatile component of bract extract responsible for the release of histamine was found to have the same properties as methyl piperonylate. Histamine release by methyl piperonylate was stimulated by propranolol hydrochloride and inhibited by isoproterenol hydrochloride and theophylline thus implicating adenosine monophosphate in the releasing process.
NIOSH-Publication; NIOSH-Grant; Histamine-liberation; Pharmacology; Enzyme-activity; Cotton-dust; Cytology; Sensitization; Drugs; Biochemical-processes; Respiratory-system
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