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Histamine release from human lung by a component of cotton bracts.

Authors
Hitchcock-M; Piscitelli-DM; Bouhuys-A
Source
Arch Environ Health 1973 Apr; 26(4):177-182
NIOSHTIC No.
00023854
Abstract
Studies to determine the localization of the histamine-releasing agent in the cotton plant revealed that only the bracts extract contained significant activity. No histamine could be detected following incubation of lung tissue with extracts of pericarps or fibers. Detectable amounts of histamine were released by the bracts extract in eight of 17 trials. The individual variation in the amount of histamine released by compound 48/80 was also wide and varied from 11.9% to 55.4% of the total histamine present. A steam volatile component of bract extract responsible for the release of histamine was found to have the same properties as methyl piperonylate. Histamine release by methyl piperonylate was stimulated by propranolol hydrochloride and inhibited by isoproterenol hydrochloride and theophylline thus implicating adenosine monophosphate in the releasing process.
Keywords
NIOSH-Publication; NIOSH-Grant; Histamine-liberation; Pharmacology; Enzyme-activity; Cotton-dust; Cytology; Sensitization; Drugs; Biochemical-processes; Respiratory-system
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
AEHLAU
CAS No.
51-45-6; 51-30-9; 61-19-8; 318-98-9; 58-55-9
Publication Date
19730401
Document Type
Journal Article
Funding Amount
513539.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
4
ISSN
0003-9896
Priority Area
Pulmonary System Disorders
Source Name
Archives of Environmental Health
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
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