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Modification of acrylamide neuropathy in rats by selected factors.

Authors
Kaplan-ML; Murphy-SD; Gilles-FH
Source
Toxicol Appl Pharmacol 1973 Apr; 24(4):564-579
NIOSHTIC No.
00023608
Abstract
A modified rotarod technique is used to determine if dietary deficiencies in pyridoxine (65236) or thiamine (59438), bilateral adrenalectomy or cortisol (50237) treatment and pretreatment with microsomal enzyme inducers (DDT (50293) or phenobarbital (57307)) would modify the course of onset and recovery from functional acrylamide neuropathy in rats. Neither pyridoxine nor thiamine deficiency nor daily injections of cortisol is found to have any measurable effect on the cumulative dose of acrylamide required to produce functional impairment. Histologic studies of peripheral nerves from acrylamide treated rats reveal that at the time of onset of functional impairment young and phenobarbital pretreated adult rats have severe peripheral nerve damage. The total cumulative doses of acrylamide required to produce neurologic deficit in DDT pretreated and phenobarbital pretreated rats are 520 and 600 milligrams per kilogram, respectively, compared to 360 milligrams per kilogram for the controls.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Neurological-diseases; Endocrine-system; Amides; Amines; Adrenal-gland-disorders; Adrenal-cortex; Adrenocortical-hormones; Drugs; Corticoids; Vitamins; Pyridines
Contact
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
CODEN
TXAPA9
CAS No.
65-23-6; 59-43-8; 50-23-7; 50-29-3; 57-30-7
Publication Date
19730401
Document Type
Journal Article
Funding Amount
274679
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00315
Issue of Publication
4
ISSN
0041-008X
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Toxicology and Applied Pharmacology
State
MA
Performing Organization
Harvard University, Boston, Massachusetts
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