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Sensory irritation of the upper airways by airborne chemicals.

Authors
Alarie-Y
Source
Toxicol Appl Pharmacol 1973 Feb; 24(2):279-297
NIOSHTIC No.
00023581
Abstract
Tests are conducted on 27 chemicals, all containing a double carbon group, to determine their potential sensory irritation properties to the upper respiratory tract when administered in aerosol form to mice. The essential molecular features for sensory irritant activity in these compounds are delineated. Correlation between the biological and chemical reactivity data suggests that these compounds initiate the sensory irritation reaction by associating with SH groups of a receptor molecule on the free nerve endings of the afferent trigeminal which are located at the surface of the nasal mucosa.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-irritants; Airborne-particles; Air-contamination; Sulfhydryls; Thiols; Sensory-perceptual-processes; Biochemistry
Contact
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
CODEN
TXAPA9
Publication Date
19730201
Document Type
Journal Article
Funding Amount
332059
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00367
Issue of Publication
2
ISSN
0041-008X
Priority Area
Pulmonary-system-disorders
Source Name
Toxicology and Applied Pharmacology
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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