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Biochemical effects of 1,1-dichloroethylene in rats: dissociation of its hepatotoxicity from a lipoperoxidative mechanism.

Authors
Jaeger-RJ; Trabulus-MJ; Murphy-SD
Source
Toxicol Appl Pharmacol 1973 Mar; 24(3):457-467
NIOSHTIC No.
00023570
Abstract
The dose response and time course of hepatic injury following oral administration of 1,1-dichloroethylene (75354) are studied in rats by measuring hepatic glucose-6-phosphatase, serum alanine-alpha- ketoglutarate transaminase, hepatic-triglyceride, and pentobarbital sleeping time, and comparison to carbon-tetrachloride (56235) in terms of the ability to stimulate lipoperoxidation in-vitro and in- vivo. Results indicate that 1,1-dichloroethylene produces some of the same liver and serum enzyme changes associated with the hepatotoxicity of carbon-tetrachloride, but the mechanisms are dissimilar.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Toxicology; Pharmacology; Hepatotoxins; Metabolism; Liver-function; Biochemistry
Contact
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
CODEN
TXAPA9
CAS No.
75-35-4; 56-23-5
Publication Date
19730301
Document Type
Journal Article
Funding Amount
274679
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00315
Issue of Publication
3
ISSN
0041-008X
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Toxicology and Applied Pharmacology
State
MA
Performing Organization
Harvard University, Boston, Massachusetts
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