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Parathion and diisopropylfluorophosphate (DFP) toxicity in partially hepatectomized rats.

Authors
Jacobsen-PL; Spear-RC; Wei-E
Source
Toxicol Appl Pharmacol 1973 Oct; 26(2):314-317
NIOSHTIC No.
00023539
Abstract
The toxic effects of parathion and diisopropylfluorophosphate (DFP) are found to increase or remain unchanged in rats after partial removal of the liver, with LD-50 values and blood cholinesterase activities used as indices of toxicity. The results are interpreted as suggesting that the toxicity of parathion is most likely not due to hepatic conversion to paraoxon.
Keywords
NIOSH-Publication; NIOSH-Grant; Pharmacology; Toxicology; Organo-phosphorus-compounds; Insecticides; Liver-functions; Enzyme-activity; Cholinesterase-inhibitors; Detoxification; Blood-chemistry; Lethal-dose; Biotransformation; Biochemical-reactions
Contact
None University of California 108 Earl Warren Hall Berkeley, Calif 94720
CODEN
TXAPA9
CAS No.
56-38-2; 311-45-5; 55-91-4
Publication Date
19731001
Document Type
Journal Article
Funding Amount
524463
Funding Type
Grant;
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00368
Issue of Publication
2
ISSN
0041-008X
Source Name
Toxicology and Applied Pharmacology
State
CA
Performing Organization
University of California Berkeley, Berkeley, California
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