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Lead toxicity in mice with genetically different levels of d-aminolevulinic acid dehydratase.

Authors
Garber-B; Wei-E
Source
Bull Environ Contam Toxicol 1973 Feb; 9(2):80-83
NIOSHTIC No.
00023277
Abstract
Lead is administered to three strains of mice with genetically different delta-aminolevulinic acid (ALA) dehydratase levels to elucidate the relationship of the enzyme to parameters of acute and subacute lead toxicity. Data are given for the lethal dose-50 of lead nitrate for the mice with different levels of ALA dehydratase activity, and for subacute lead toxicity in mice fed a 4% lead carbonate diet, using body weight, liver and kidney weight, hematocrit, and enzyme inhibition as indices. Results indicate that inhibition of ALA dehydratase activity is not related to acute or subacute lead toxicity as measured by physiological parameters.
Keywords
NIOSH-Publication; NIOSH-Grant; Sulfhydryl-enzymes; Porphyrin-synthesis; Pharmacology; Toxic-substances; Bioassay; Lead-poisoning; Enzyme-activity; Acute-poisoning; Metal-poisoning
Contact
Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
CODEN
BECTA6
CAS No.
106-60-5; 7439-92-1; 598-63-0; 10099-74-8
Publication Date
19730201
Document Type
Journal Article
Funding Amount
608432.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-OH-00020
Issue of Publication
2
ISSN
0007-4861
Source Name
Bulletin of Environmental Contamination and Toxicology
State
CA
Performing Organization
University of California Berkeley, Berkeley, California
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