Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The effect of lung antibody on normal lung structure and function.

Authors
Burrell-R; Flaherty-DK; DeNee-PB; Abraham-JL; Gelderman-AH
Source
Am Rev Respir Dis 1974 Jan; 109(1):106-113
NIOSHTIC No.
00023125
Abstract
The effect of passive immunization is studied in normal mice treated with homologously derived mouse lung antibody during a 9-week period. Pathologic changes result although the antisera are not acutely pneumotoxic. The antibody is found to localize in the focal areas on the alveolar septa as evidenced by immunofluorescence and to cause a monocytic infiltrate and necrosis of the lung as evidenced by increases in lactic dehydrogenase isoenzymes 2 and 3. After 4 weeks of treatment, the animals show distension of the airways distal to the terminal bronchioles, increased interstitial alveolar connective tissue, and an increased localization in the lung of bacteria that are cleared from the circulation. Similar changes might account for increased susceptibility to respiratory infection in persons with chronic respiratory disease.
Keywords
NIOSH-Publication; NIOSH-Grant; Sensitization; Immunologic-tests; Immunopathology; Enzyme-activity; Respiratory-disorders; Immunologic-techniques; Lung-clearance; Respiratory-functions; Tissue-reactions; Toxicity; Bacterial-infection; Lung-disorders
Contact
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
CODEN
ARDSBL
Publication Date
19740101
Document Type
Journal Article
Funding Amount
289015
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00360
Issue of Publication
1
ISSN
0003-0805
Source Name
American Review of Respiratory Disease
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
TOP