Expectancy Calculations for Histological Types of Bronchogenic Carcinoma among Uranium Miners.
Archer-VE; Saccomanno-G; Jones-JH
NIOSH (Unpublished paper presented at the meeting of the AAAS, June 11-15, 1973), 1973 Mar:12 pages
By use of calculations of expected numbers for each of the major histologic types of bronchogenic carcinoma, it was shown that epidermoid, small cell undifferentiated and adenocarcinomas are all increased among uranium (7440611) miners. Small cell undifferentiated was the predominant type and was the only one that was significantly elevated in all cumulative radiation exposure groups. It was noted that the same three groups have been shown to be elevated among cigarette smokers, but with different relative frequencies. Other histologic types (large cell undifferentiated, carcinoid, bronchiolo-alveolar, and bronchial gland tumors) were not elevated in frequency. This data supports the hypothesis that small cell undifferentiated and epidermoid carcinomas of the lung are closely related, and are the principal types whose frequency is increased by inhaled carcinogens, even though adenocarcinomas are also increased to some extent. The frequency of other histologic types (with the probable exception of combined adeno-epidermoid) is apparently unaffected by inhaled carcinogens in man. In all analyses of histologic types of bronchogenic carcinoma, large cell and small cell undifferentiated types should be separated.
Carcinogenesis; Radiation; Mining; Statistics;
Western Area Occupational Health Laboratory, National Institute for Occupational Safety and Health, Department of Health, Education, and Welfare (Unpublished; Paper presented at the meeting of the AAAS, June 11-15, 1973), 12 pages, 9 references