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Adaptation to the toxic effects of lead.

Authors
Garber-B; Wei-E
Source
Am Ind Hyg Assoc J 1972 Nov; 33(11):756-760
NIOSHTIC No.
00020595
Abstract
In an experimental study, the susceptibility of male white albino mice to lead toxicity after pretreatment with a small intraperitoneal dose of lead nitrate was examined. Indices of lead toxicity chosen for study were lethality, body weight loss, liver and kidney weight changes, hematocrit, and inhibition of liver delta- aminolevulinic acid dehydratase activity. Pretreatment with lead nitrate (10 or 20 mg/kg intraperitoneal) protected mice against the acute lethal effects of a 200-mg/kg intraperitoneal dose of lead nitrate, the optimal time of pretreatment being 4 days before the challenge dose. Pretreatment with lead nitrate (20 mg/kg intraperitoneal) did not attenuate and may have exacerbated the subacute lead toxicity induced by a 4% basic lead carbonate diet fed over a 12-day period. It appears that only selected biological parameters develop resistance to lead.
Keywords
NIOSH-Publication; NIOSH-Grant; Levulinic-acids; Adaptation
Contact
Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
CODEN
AIHAAP
CAS No.
7439-92-1; 10099-74-8; 598-63-0
Publication Date
19721101
Document Type
Journal Article
Funding Amount
608432.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-OH-00020
Issue of Publication
11
ISSN
0002-8894
Source Name
American Industrial Hygiene Association Journal
State
CA
Performing Organization
University of California Berkeley, Berkeley, California
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