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Remission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literature.

Authors
Seaton-A; Meland-JM; Lapp-NL
Source
Thorax 1971 Nov; 26(6):683-688
NIOSHTIC No.
00018903
Abstract
Two patients with Goodpasture's syndrome are reported. One showed an apparently spontaneous remission and has survived in good health for over five years since the onset of his illness; he was treated for part of this time with steroids and chlorambucil. The second patient failed to respond to steroids but appeared to improve rapidly from a moribund state on administration of azathioprine; he remains well, although in mild renal failure, over a year later. The management of 35 other patients reported to have survived this illness is reviewed. It appears that both the renal and pulmonary features of Goodpasture's syndrome may undergo spontaneous remission, and that the latter can sometimes be suppressed with steroid or immunosuppresant therapy. On four occasions the pulmonary manifestations of the disease have been arrested by nephrectomy.
Keywords
NIOSH-Author; Physiological-effects; Kidney-disorders; Respiratory-disorders; Morbidity-data; Medical-treatment
CODEN
THORA7
CAS No.
446-86-6; 305-03-3
Publication Date
19711101
Document Type
Journal Article
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0040-6376
Source Name
Thorax
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