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In vitro lymphocyte responses in contact hypersensitivity II.

Authors
Milner-JE
Source
J Invest Dermatol 1971 May; 56(5):349-352
NIOSHTIC No.
00012273
Abstract
To determine whether lymphocyte transformation in-vitro in response to hapten skin protein conjugates is specific as well as sensitive, guinea-pigs were made sensitive to either of two contact allergens, dinitrofluorobenzene (70348) and p-phenylenediamine (106503). Sensitization was accomplished by footpad injections of the conjugated hapten. Lymphocytes from animals with contact hypersensitivity to the two allergens were cultured in-vitro with conjugates of guinea-pig epidermal proteins with the same allergens. Responses to these antigens indicate that lymphocyte transformation in-vitro, in the presence of the appropriate conjugate, can distinguish between sensitivity to either of these antigens.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Allergic-reactions; Skin-disorders; Immunology; White-blood-cells; Amines; Fluorinated-benzenes
Contact
Environmental Health University of Washington Dept of Environ Health Seattle, Wash 98105
CODEN
JIDEAE
CAS No.
70-34-8; 106-50-3
Publication Date
19710501
Document Type
Journal Article
Funding Amount
140693.00
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00321
Issue of Publication
5
ISSN
0022-202X
Priority Area
Dermatitis
Source Name
Journal of Investigative Dermatology
State
WA
Performing Organization
University of Washington, Seattle, Washington
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