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Responses of alveolar macrophages to metals I. Inhalation of lead and nickel.

Authors
Bingham-E; Barkley-W; Zerwas-M; Stemmer-K; Taylor-P
Source
Arch Environ Health 1972 Dec; 25(6):406-414
NIOSHTIC No.
00012204
Abstract
Histopathological examination of lungs by light microscopy, and measurement of the number of alveolar microphages available by a standard washing procedure, for animals subjected to inhalation of soluble and insoluble aerosols of lead or nickel, Pb-C12, Pb2-03, Ni- C12, and NiO, near or below the levels proposed as acceptable for occupational exposures. The number of available macrophages increased for NiO, decreased for Pb2-03, and was not changed for Pb- Cl2, and Ni-Cl1. However, distribution in cell sizes varied with exposure. Observed histopathological changes from nickel compounds are cited as requiring a lowering of the threshold limit value for nickel and nickel compounds.
Keywords
NIOSH-Publication; NIOSH-Grant; Respiratory-system-disorders; Metal-poisoning; Air-contaminants; Airborne-particles; TLV; Physiological-effects; Cytology; Toxicology
Contact
Environmental Health University of Cincinnati College of Medicine Cincinnati, Ohio 45219
CODEN
AEHLAU
CAS No.
7439-92-1; 7440-02-0; 7758-95-4; 1314-37-8; 7718-54-9; 1313-99-1
Publication Date
19721201
Document Type
Journal Article
Funding Amount
64457
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00335
Issue of Publication
6
ISSN
0003-9896
Priority Area
Respiratory-system-disorders
Source Name
Archives of Environmental Health
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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