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Respiratory uptake of ozone in dogs.

Authors
Yokoyama-E; Frank-R
Source
Arch Environ Health 1972 Aug; 25(2):132-138
NIOSHTIC No.
00012203
Abstract
Measurement of the uptake of ozone by the surgically isolated upper airways in 11 anesthetized, paralyzed, mechanically ventilated dogs. The gas was administered either by nose or mouth, each exposure lasting 20 to 30 minutes. The relative uptake of ozone was found to be inversely related to concentration and flow rate, and was higher nasally than orally. Changes in nasal flow resistance, induced by aerosols of histamine and phenylephrine hydrochloride, had little effect on the process. The removal of ozone from inspired air by the lower airways and parenchyma was measured in five additional dogs that were mechanically ventilated through a tracheal cannula. The concentration ranged from 0.20 parts per million (ppm) to 0.85 ppm; the tidal volume was constant, and the pump frequently was either 20 or 30 cycles per minute. Under these circumstances, the rate of uptake varied between 80 percent and 87 percent.
Keywords
NIOSH-Publication; NIOSH-Grant; Respiration; Respiratory-functions; Gases; Breathing; Inspiration
Contact
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
CODEN
AEHLAU
CAS No.
10028-15-6; 61-76-7; 51-45-6
Publication Date
19720801
Document Type
Journal Article
Funding Amount
420211
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00340
Issue of Publication
2
ISSN
0003-9896
Source Name
Archives of Environmental Health
State
WA
Performing Organization
University of Washington, Seattle, Washington
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