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Irradiation-induced lesions in germfree rats.

Authors
Pollard-M; Sharon-N
Source
J Natl Cancer Inst 1971 Jul; 47(1):229-234
NIOSHTIC No.
00012115
Abstract
Radiological study of irradiation induced lesions in germ free rats. Germfree Wistar and Fischer rats were subjected to whole body sublethal doses of X-rays and many developed malignant and benign neoplastic and degenerative lesions within 15 minutes. Untreated, germ free, control rats of the same age were disease free. Control, untreated, conventional Wistar rats, at age 15 months, had developed an extensive array and high incidence of malignant and benign neoplasms, degenerative lesions, and lung infections. The source and nature of pathogens in the environment of conventional rats were not determined. A life shortening effect of X-irradiation was not demonstrated, because rats were killed for examinations.
Keywords
NIOSH-Publication; NIOSH-Grant; Radiology; Ionizing-radiation; Cancer; Respiratory-disorders; Carcinogenesis
Contact
Lobund Laboratory University of Notre Dame Lobound Laboratory Notre Dame, Ind 46556
CODEN
JNCIAM
Publication Date
19710701
Document Type
Journal Article
Funding Amount
63044.00
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00342
Issue of Publication
1
ISSN
0027-8874
Source Name
Journal of the National Cancer Institute
State
IN
Performing Organization
University of Notre Dame, Notre Dame, Indiana
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