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Ion and macromolecular transport in the alveolar macrophage.

Authors
Robin-ED; Smith-JD; Tanser-AR; Adamson-JS; Millen-JE; Packer-B
Source
Biochim Biophys Acta 1971 Jul; 241(1):117-128
NIOSHTIC No.
00012114
Abstract
Some aspects of sodium, potassium, and chloride ion transport and macromolecular transport have been studied in isolated rabbit alveolar macrophages. The steady-state intracellular concentrations in Ringer's solution are presented for the three ions in terms of milliequivalents per kilogram cell water. The two rate constants, rapid phase and slow phase, are given for the sodium ion efflux. It appears that this cell has high permeability for sodium ion and the high leak down the electrochemical gradient requires a high rate of active transport. Classical relatively high molecular weight extracellular markers are excluded from cell water; however, ferritin (molecular weight 465,000) influx is rapid with intracellular/extracellular concentrations greater than 1.0 within 3 minutes. Simultaneous exposure of cells to both ferritin and dextran leads to no measurable increase in cellular dextran uptake suggesting high specificity for ferritin uptake.
Keywords
NIOSH-Publication; NIOSH-Grant; Cytology; Biophysical-effects; Cell-mechanics; Pulmonary-functions; Phagocytosis; Ion-exchange; PM9004540; Biochemical-effects; PM9007732
Contact
Physiology Stanford University Sch of Med Department of Medicine Palo Alto, Calif
CODEN
BBACAQ
CAS No.
7778-80-5; 10233-01-9; 7646-93-7; 7647-14-5
Publication Date
19710706
Document Type
Journal Article
Funding Amount
668550
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00352
Issue of Publication
1
ISSN
0006-3002
Source Name
Biochimica et Biophysica Acta
State
CA
Performing Organization
Stanford University, Stanford, California
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