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Program in occupational biomechanics: The effect of a muscle relaxant on the biomechanics of the patella reflex.

Authors
Jarvik-RK
Source
New York University Center for Safety, and Institute of Rehabilitation Medicine, New York University Medical Center, New York, N. Y., Master of Arts Thesis, 1971 Jan; :1-33
Link
NIOSHTIC No.
00012039
Abstract
Thesis submitted to the New York University on the development of a device and technique for the simple and direct measurement of the biomechanical parameters of reflex movement, such as displacement, velocity, and acceleration. The biomechanical profile of the patella reflex of healthy subjects was studied. Testing was conducted with no medication, following administration of placebo, and following a single 10 milligram oral dose of diazepam. The effects of Jendrassik and arm exercise facilitation were studied. Diazepam caused a lengthening of reaction time and decreased maximum displacement, velocity, acceleration, and the vector sum of velocity and acceleration. Exercise facilitation following diazepam was highly effective, returning the reflex to almost its pre-drug condition. Placebo had no effect. Results indicate that Jendrassik and arm exercise facilitation exert their effects upon the patella reflex by augmenting recruitment of fast motor units, composed of white fibers, that diazepam blocks recruitment of the faster units, and that exercise facilitation circumvents this block. Diazepam is thought to affect reflex by decreasing supraspinal excitation. The data obtained are consistent with a principal site of action of diazepam upon the excitatory reticular formation.
Keywords
NIOSH-Grant; Biomechanics; Reflex-action; Bioassay; Muscle-relaxants; Placebos; Drugs
Contact
Rehabilitation Medicine New York University Med Ctr 400 East 34 Street New York, N Y 10016
CAS No.
439-14-5
Publication Date
19710101
Document Type
Dissertation
Funding Amount
477334
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
PB90-114935
NTIS Price
A04
Identifying No.
Grant-Number-T01-OH-00103
Source Name
New York University Center for Safety, and Institute of Rehabilitation Medicine, New York University Medical Center, New York, N. Y., Master of Arts Thesis, 33 pages, 37 references
State
NY
Performing Organization
New York University, New York, New York
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