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Reduction of ketones in liver cytosol.

Authors
Leibman-KC
Source
Xenobiotica 1971 Jan; 1(1):97-104
NIOSHTIC No.
00011898
Abstract
Determination of location and some characteristics of enzymatic reduction of ketones in liver homogenates of rats and rabbits, incubated with ketones (acetone, 2-butanone, acetophenone, benzophenone, deoxybenzoin, metyrapone) or alcohols (isopropanol, 2- butanol, 1-phenylethonol, benzhydrol, 1,2-diphenylethanol, metyropol). The predominant site for the hepatic reduction of aromatic and aliphatic ketones is the cytosol. Acetophenone reductase activity is not enhanced in liver cystol after treatment of rats with phenobarbital. Ketone reductase activity was found in the cytosol fractions of some non-hepatic tissues, particularly that of the kidney.
Keywords
NIOSH-Publication; NIOSH-Grant; Metabolism; Liver-functions; Kidney-functions; Enzyme-activity
Contact
Pharmacology and Therapeutics Univ of Florida Coll of Med Dept of Pharma & Therapeutics Gainesville, Fla 32601
CODEN
XENOBH
CAS No.
67-64-1; 78-93-3; 98-86-2; 78-92-2; 91-01-0; 119-61-9; 67-63-0; 54-36-4; 98-85-5
Publication Date
19710101
Document Type
Journal Article
Funding Amount
460733
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00316
Issue of Publication
1
ISSN
0049-8254
Source Name
Xenobiotica
State
FL
Performing Organization
University of Florida Gainesville, Gainesville, Florida
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