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Papain-induced emphysema and the elimination of TiO2 particulates from the lungs.

Authors
Ferin-J
Source
Am Ind Hyg Assoc J 1971 Mar; 32(3):157-162
NIOSHTIC No.
00010590
Abstract
In order to study the pulmonary clearance of particulates, the deposition, retention, and clearance of titanium dioxide (TiO2) particles in normal rats under varying conditions were determined. Assuming that the particle parameters are constant, the deposition can be predicted if the lung weight, concentration of TiO2 in the air, and time of exposure are known. The clearance of particles was followed up to 140 days. The retention half-time after exposure is 14 days for approximately the first 8 days and 88 days thereafter. Experimental emphysema produced by aerosol inhalation and intratracheal injection of papain reduces the clearance rate of TiO2 particles.
Keywords
NIOSH-Publication; NIOSH-Grant; Lung-clearance; Titanic-oxide; PM9001734
Contact
Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
CODEN
AIHAAP
CAS No.
1309-63-3
Publication Date
19710301
Document Type
Journal Article
Funding Amount
292984.00
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00334
Issue of Publication
3
ISSN
0002-8894
Source Name
American Industrial Hygiene Association Journal
State
NY
Performing Organization
University of Rochester, Rochester, New York
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