Papain-induced emphysema and the elimination of TiO2 particulates from the lungs.
Am Ind Hyg Assoc J 1971 Mar; 32(3):157-162
In order to study the pulmonary clearance of particulates, the deposition, retention, and clearance of titanium dioxide (TiO2) particles in normal rats under varying conditions were determined. Assuming that the particle parameters are constant, the deposition can be predicted if the lung weight, concentration of TiO2 in the air, and time of exposure are known. The clearance of particles was followed up to 140 days. The retention half-time after exposure is 14 days for approximately the first 8 days and 88 days thereafter. Experimental emphysema produced by aerosol inhalation and intratracheal injection of papain reduces the clearance rate of TiO2 particles.
NIOSH-Publication; NIOSH-Grant; Lung-clearance; Titanic-oxide; PM9001734
Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
American Industrial Hygiene Association Journal
University of Rochester, Rochester, New York