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Observations concerning alveolar dust clearance.

Authors
Ferin-J
Source
Department of Radiation Biology and Biophysics, School of Medicine and Dentistry (Unpublished; Presented at the International Conference on Coal Workers' Pneumoconiosis, New York, September 13-17, 1971), Rochester, New York, 1971 Sep; :1-18
Link
NIOSHTIC No.
00008980
Abstract
Experiments with rats exposed to titanium-dioxide (7440326) dust reveal that the onset of alveolar clearance is immediate in terms of minutes, overlapping in time with the rapid clearance of particles from the tracheobronchial tree. Two days after the onset of exposure the number of alveolar macrophages is significantly increased. In 88 days (half time), 50 percent of the initial lung burden is cleared. Multiple exposures may change the clearance rate. Clearance efficiency may improve by experimental means. Lung clearance of titanium-dioxide in animals subjected to preliminary exposure to sulfur-dioxide (7446095) is significantly depressed.
Keywords
NIOSH-Grant; Respiratory-functions; Lung-clearance; Respiratory-mechanics; Inorganic-gases; Toxic-gases; Dust-inhalation; Lung-dust-burden
Contact
Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
CAS No.
7440-32-6; 7446-09-5
Publication Date
19710913
Document Type
Conference/Symposia Proceedings
Funding Amount
292984
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00334
Source Name
Department of Radiation Biology and Biophysics, School of Medicine and Dentistry (Unpublished; Presented at the International Conference on Coal Workers' Pneumoconiosis, New York, September 13-17, 1971), Rochester, New York, 18 pages, 26 references
State
NY
Performing Organization
University of Rochester, Rochester, New York
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