Comparison of laboratory-measured plasma and salivary osmolality with salivary osmolality determined by a hand-held osmometer in acute 3%-5% dehydration status– FY09
NOTE: This page is archived for historical purposes and is no longer being maintained or updated.
The objective of this study is:
To determine the accuracy of salivary osmolality measurements taken with a new hand-held osmometer compared to a standard laboratory osmometer using freeze point depression technology during states of acute, mild dehydration (3%, 5%),
To evaluate any correlation between salivary osmolality by both pieces of equipment with plasma osmolality measured by the standard laboratory osmometer
To examine the effect of various subject characteristics (i.e., age, gender, fitness, smoking) upon readings from the hand-held salivary osmometer.
This study may require ~60 subjects to complete all phases. If the hand-held osmometer is found to be accurate, this could allow for detection of early dehydration in populations at risk (e.g., firefighters, military personnel, roofers, agricultural workers, etc.).
Q1 Send draft protocol to TSWG for approval (completed, December, 2008) and Send draft dehydration protocol out for peer-review (completed, January 2009)
Q2 Submit draft protocol to HSRB for approval and Obtain HSRB approval and begin subject recruitment (Spring, 2009)
Q3 Recruit an initial 30 subjects, complete first phase (medical screening, GXT) and second phase (dehydration induction and laboratory measurements) of dehydration study (Fall of 2010)
Q4 Complete third phase of dehydration study (dental appliance use, SCBA use)
Final Report to the client (TSWG)
Publications in peer-reviewed journals
Guidance documents to key stakeholders on thermal stress monitoring
Use of data in the development and modification of standards (ASTM, ISO) related to heat stress and hydration status.