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Risk Based Permeation Criteria - FY07

NOTE: This page is archived for historical purposes and is no longer being maintained or updated.


  • Examine existing toxicity data for selected toxic industrial chemicals (TICs) to determine ratios of acceptable dermal to inhalation doses and create detailed permeation procedures in parallel to apply criteria.
Skin Toxicity model and Permeation test

Applicable Standards

  • NFPA Protective Clothing Standards - 1991, 1994, 1971, 1951
  • ASTM F739 Standard Test Method for Resistance of Protective Clothing Materials to Permeation by Liquids or Gases Under Conditions of Continuous Contact

Key Partners

  • NFPA
  • TSWG (Funded in part by TSWG)
  • ASTM International


  • Emergency Responders
  • Manufacturers
  • Test Laboratories

Project Scope

  • Determine new permeation test end points for TICs that are toxicity-based.
  • Develop uniform permeation testing parameters and procedures to increase ease and reproducibility.
  • Provide new permeation criteria and test methods to standards to lessen over design of barrier protective clothing.


  • Collection of dermal/inhalation toxicity data for selected TICs Collection of dermal/inhalation toxicity data for selected TICs.
  • Evaluation of skin permeation models.
  • Analysis of dermal and respiratory toxicity data and development of model for predicting acceptable doses..


  • Manuscripts published or submitted to peer review journals (approx. 1)
  • Presentations to stakeholders or conferences (approx. 3)
  • Standards committee meetings & public meetings (approx.8)
  • Final report with technical data including recommended criteria/end points and methods for permeation testing for use by the NFPA Technical Committees and ASTM F23.
  • Model that predicts acceptable doses for selected TICs which could be expanded to additional TICs.


  • Revisions or updates to NFPA 1994, NFPA 1971, NFPA 1991, NFPA 1951 and ASTM F739.
Page last modified: July 23, 2007
Page last reviewed: July 23, 2007 (archived document)
Content Source: National Institute for Occupational Safety and Health (NIOSH)