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NIOSH - National Institute for Occupational Safety and Health
NIOSH Hearing Loss Research Program Review NIOSH Publications on Noise and Hearing The National Academies - Advisors to the Nation on Science, Engineering, and Medicine

What has the program achieved?

In this section ....

Research Goal 1

Research Goal 2

Research Goal 3

Research Goal 4

Acronym Finder

Outputs and Transfer - Research Goal 4.5:
Prevent hearing loss by understanding the role of genetics in susceptibility to noise

Intermediate Outcomes
Intermediate outcomes are expected in the future as genetic susceptibility to hearing loss is better-understood. A search of the annual conference abstracts for the Association for Research in Otolaryngology for the search terms “noise susceptibility” returned 0 results for 1992 and 1993, 4 abstracts in 1994, increasing to 12 abstracts in 1999 and 2001.

>> View What's Ahead for this Research Subgoal

Publications:

Journal Articles

Davis RR, Cheever ML, Krieg EF, Erway LC [1999]. Quantitative measure of genetic susceptibility to noise-induced hearing loss in two strains of mice. Hearing Research, 134:9-15. Cited at least 6 times.

Davis RR, Kozel P, Erway LC [2003]. Genetic influences in individual susceptibility to noise: A review. Noise and Health, 5(20):19-28.

Davis RR, Newlander JK, Ling X-B, Cortopassi G, Krieg EF, Erway LC [2001]. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hearing Research 155: 82-90. (17 known citations)

Erway LC, Shiau Y-W, Davis RR, Krieg, E [1996]. Genetics of age-related hearing loss in mice: III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hearing Research,93:181-87. (47 known citations)

Kozel PJ, Davis RR, Krieg EF, Shull GE, Erway LC [2002]. Deficiency in Plasma Membrane Calcium ATPase Isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hearing Research, 164: 231-239. (7 known citations)

Presentations

Conferences

Davis RR[1996]. “Beating the Drum: Basic Research in Noise-Induced Hearing Loss” Departmental Seminar, Department of Biological Sciences, University of Cincinnati, Nov. 4.

Davis RR [1999]. Noise, genes and the ear: Searching for the foundations of susceptibility. Scientist Session, 1999 Public Health Professional Conference of the U.S.PHS Commissioned Officers Association.

Davis RR, Erway LC[2002]. Genetic influences in Individual Susceptibility to Noise Damage. Individual Susceptibility to Noise Damage. European Commission Concerted Action NOPHER (Noise Pollution Health Effects Reduction). 19-20 July 2002. Novartis Foundation, London, UK.

Theses

Cheever ML [1996]. The C57BL/6J and CBA/CaJ strains of mice exhibit different auditory thresholds in response to intensity of noise exposure. Master of Science in Biological Sciences, University of Cincinnati.

Nolte ML [2005]. The effects of noise exposure at various ages on Ahl gene expression. Master of Arts in Audiology, University of Cincinnati.

Shiau Y-W [1994]. The susceptibility of four strains of mice to noise-induced hearing loss. Doctor of Philosophy in Audiology, University of Cincinnati.

Posters

Bohne B, Newlander MK, Erway LC, Davis RR, Krieg E, Ling X-B, Cortopassi GA [1996]. Mice carrying two copies of an age-related hearing loss gene (Ahl) sustain more noise damage than those carrying one copy. The 19th Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida.

Davis RR, Kozel P, Erway LC [2003]. A proposed mechanism of the gene Ahl for increased susceptibility to noise-induced hearing loss. 25th Midwinter Meeting, Association for Research in Otolaryngology, Daytona Beach, Florida.

Davis RR, Shiau Y-W, Erway LC [1994]. Temporary threshold shift does not predict permanent threshold shift in a " low-frequency" exposure of mice. Effects of Noise on Hearing: 5th International Symposium, Gothenburg, Sweden, May 12-14, 1994.

Ling X-B, Erway LC, Newlander JK, Davis RR, Cortopassi GA [1995]. Mapping of a mouse gene for noise-induced hearing loss. The 18th Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida.

Newlander JK, Erway LC, Davis RR, Cortopassi G, Ling X-B [1995]. Susceptibility to NIHL and age-related hearing loss in mice. The 18th Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida.

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