Outputs and Transfer - Research Goal 4.4:
Improve detection and prevention of occupational hearing loss
by understanding the aging component
This causative mechanisms effort provides the basic science underpinnings to help understand the age-related hearing thresholds in the U.S. population obtained through our efforts in the NHANES survey.
The 1996 initial publication from this research was influential. “Genetics of age-related hearing loss in mice: III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss” by Erway, Shiau, Davis and Krieg appeared in “Hearing Research” and has been cited at least 47 times. A number of other articles, presentations, and posters followed (see supporting evidence).
In 2003, the HLR program organized a four day conference, “The Mouse as an Instrument for Hearing Research,” that was held in Bar Harbor, Maine. This conference brought molecular genetics researchers and hearing researchers together for the first time. A number of conference attendees have developed informal and formal collaborations. A second meeting was held in October, 2005, also at Jackson Laboratory. The journal, “Molecular Brain Research,” has agreed to publish papers from the 2005 conference.
The proceedings of the 2003 conference were published on the Jackson Laboratory website. The proceedings of the 2005 Jackson Laboratory meeting will be published in a special issue of Molecular Brain Research journal due out in February, 2006.
This research has not yet generated outcomes.
Franks JR, Davis RR. Longitudinal Studies of Age and Noise Effects: ANSI Databases.
Henderson D, Hamernik RP . Uncertainties of present hearing damage risk criteria. noisexpo: Proceedings of the Technical Program, Bay Village, Ohio. Acoustical Publications, Inc: 165-169.
Cheever ML . The C57BL/6J and CBA/CaJ strains of mice exhibit different auditory thresholds in response to intensity of noise exposure. Master of Science in Biological Sciences, University of Cincinnati.
Nolte ML . The effects of noise exposure at various ages on Ahl gene expression. Master of Arts in Audiology, University of Cincinnati.
Shiau Y-W . The susceptibility of four strains of mice to noise-induced hearing loss. Doctor of Philosophy in Audiology, University of Cincinnati.
Franks J, Davis RR. Longitudinal Studies of Age and Noise Effects: ANSI Databases. Consensus Meeting Noise and Ageing. MRC Institute of Hearing Research and the Hearing Research Trust, November 4-6,2002. Nottingham, England.
Davis RR, Erway LC . Genetic influences in Individual Susceptibility to Noise Damage. Individual Susceptibility to Noise Damage. European Commission Concerted Action NOPHER (Noise Pollution Health Effects Reduction). 19-20 July 2002. Novartis Foundation, London, UK
Davis RR, Kozel P, Erway LC . A proposed mechanism of the gene Ahl for increased susceptibility to noise-induced hearing loss. 25th Midwinter Meeting, Association for Research in Otolaryngology, Daytona Beach, Florida.
Davis RR, Shiau Y-W, Erway LC . Temporary threshold shift does not predict permanent threshold shift in a " low-frequency" exposure of mice. Effects of Noise on Hearing: 5th International Symposium, Gothenburg, Sweden, May 12-14, 1994.
Ling X-B, Erway LC, Newlander JK, Davis RR, Cortopassi GA. Mapping of a mouse gene for noise-induced hearing loss. The 18th Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida.
Newlander JK, Erway LC, Davis RR, Cortopassi GA, Ling X-B . Susceptibility to NIHL and age-related hearing loss in mice. The 18th Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida.
 Davis, R.R.  Noise-induced hearing loss. In Willott, J. F. Handbook of Auditory Research: From Behavior to Molecular Biology, CRC Press, Boca Raton, FL. Pp 477-88.