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NIOSH Respiratory Diseases Research Program

Evidence Package for the National Academies' Review 2006-2007

Appendix List - Chapter 4

previous Appendix List - Chapter 3 | Appendix List - Chapter 5 next


The reports providing evidence of prevalence of, or axacerbation of, asthma due to workplace conditions.


Protocol Version 6.0 Final Draft March 15, 2005: Protocol to Implement and Evaluate a Model Medical Surveillance Program for Occupational Asthma (OA) and to Characterize the Incidence of OA Associated with Toluene Diisocyanate Exposure in the Production Environment


Zeiss CR, Gomaa A, Murphy FM, Weissman DN, Hodgson M, Foster D, Dejativongse S, Colella K, Kestenberg K, Kurup VP, Bush RK, Chiu AM, Kelly KJ, Fink JN. Latex Hypersensitivity in Department of Veterans Affairs health care workers: glove use, symptoms, and sensitization. Annals of Allergy, Asthma, and Immunology. V91, December 2003. p 539-545.


NIOSH Alert:  Preventing Allergic Reactions to Natural Rubber Latex in the Workplace. DHHS [NIOSH] Publication No. 97-135. Washington, DC: U.S. Government Printing Office, 1997


NIOSH [1998]. Latex Allergy: A Prevention Guide. NIOSH Publication No. 98-113


Maxfield AM, Lewis MJ, Tisdale JA, Lachenmayr S; Lum M. Effects of a preventive message in the organizational context: occupational latex allergy in hospitals. Am J Ind Med 1999 Sep; 36(S1):125-127.


Maxfield A. Lewis J, Lachenmayr S, Tisdale J, Lum M. A National Institute for Occupational Safety and Health Alert sent to hospital sand the intentions of hospital decision makers to advocate for latex allergy control measures. Health Education Res. V15(4)2000 p463-467.


Biagini R, Krieg E,; Pinkerton L, Hamilton R. Receiver operating characteristics analyses of food and drug administration-cleared serological assays for natural rubber latex-specific immunoglobulin E antibody. Clin Diagn Lab Immunol 2001 Nov; 8(6):1145-1149.


List of 10 publications citing the RDRP Latex alert


List of 61 RDRP products concerning isocyanate asthma


NIOSH Alert: Preventing Asthma and Death from Diisocyanate Exposure DHHS [NIOSH] Publication No. 96-111. Washington, DC: United States Government Printing Office, 1996


NIOSH Alert: Prevening Asthma and Death from MDI Exposure During Spray-On Truck Bed Liner and Related Applications.


The Washington Sate Department of Labor and Industries issued a Hazard Alert entitled “Spray-on Urethane Truck Bed Linings and Isocyanate Exposures” in March 2003


The Michigan Occupational and Safety Health Administration (MIOSHA) issued a Hazard Alert entitled “Spray-on Truck-bed Liner Operation Proves Fatal” in October 2003


David K. Bonauto, MD, MPHAustin D. Sumner, MD, MPHChristy C. Curwick, MPHStephen G. Whittaker, PhDDon J. Lofgren, MPH, CIH Work-Related Asthma in the Spray-On Truck Bed Lining Industry JOEM • Volume 47, Number 5, May 2005 p514-517


Don J. Lofgren,1 Terry L. Walley,1 Phillip M. Peters,2 and Marty L. Weis3. MDI Exposure for Spray-On Truck Bed Lining Applied Occupational and Environmental Hygiene, 18: 772–779, 2003


Matheson JM, Lemus R, Lange RW, Karol MH, Luster MI. Role of tumor necrosis factor in toluene diisocyanate asthma.Am J Respir Cell Mol Biol, 2002 Oct 27(4):396-405.


Petsonk EL, Wang ML, Lewis DM, Siegel P, Husberg B. Asthma-like symptoms in wood product plant workers exposed to methylene diphenyl diisocyanate. Chest 2000 Oct; 118(4):1183-1193.


"Occupational Asthma: In and Out of the Workplace" A Conference on the Basic Mechanisms of Occupational Asthma April 30 to May 2, 1998

A4-20 Part 1
A4-20 Part 2

The International Conference on Occupational & Environmental Exposures of Skin to Chemicals: Science & Policy , September 8-11, 2002


NIOSH numbered document 2004-116 entitled “Issues Related to Occupational Exposure to Isocyanates, 1989 to 2002,”


Bello D. Woskie SR. Streicher RP. Liu Y. Stowe MH. Eisen EA. Ellenbecker MJ. Sparer J. Youngs F. Cullen MR. Redlich CA. Polyisocyanates in occupational environments: a critical review of exposure limits and metrics.  American Journal of Industrial Medicine 2004; 46:480-91.


Streicher RP, Reh CM, Key-Schwartz RJ, Schlecht PC, Cassinelli ME, O'Connor PF [2000]. Determination of Airborne Isocyanate Exposure: Considerations in Method Selection. AIHAJ 61:544-556.


Streicher RP, Arnold JE, Ernst MK, Cooper CV [1996]. Development of a Novel Derivatization Reagent for the Sampling and Analysis of Total Isocyanate Group in Air and Comparison of its Performance with that of Several Established Reagents. AIHAJ 57:905-913.


Streicher RP, Kennedy ER, Lorberau CD [1994]. Strategies for the Simultaneous Collection of Vapours and Aerosols with Emphasis on Isocyanate Sampling. Analyst 119:89-97


Wang ML, Petsonk EL. Symptom onset in the first 2 years of employment at a wood products plant using diisocyanates: some observations relevant to occupational medical screening. Am J Ind Med 2004 Sep; 46(3):226-233.


Ortega HG. Weissman DN. Carter DL. Banks D. Use of specific inhalation challenge in the evaluation of workers at risk for occupational asthma: a survey of pulmonary, allergy, and occupational medicine residency training programs in the U.S. and Canada. Chest. 121:1323-1328, 2002.


Weissman DN. Lewis DM. Is specific antibody determination diagnostic for asthma attributable to low-molecular-weight agents? Occupational Medicine. 15:385-98, 2000.


D. M. Wild, C. A. Redlich, and A. D. Paltiel. Surveillance for isocyanate asthma: a model based cost effectiveness analysis. Occupational & Environmental Medicine 62:743-749, 2005.


In 2006, RDRP established a NIOSH Web page that provides a single source of published references to the primary prevention of occupational asthma due to diisocyanates as well as other agents  []


Park J-H, Schleiff PL, Attfield MD, Cox-Ganser JM, Kreiss K.  Building-related Respiratory Symptoms Can Be Predicted with Semi-quantitative Indices of Exposure to Dampness and Mold.  Indoor Air, 15: 425-433, 2004.


Cox-Ganser JM, White SK, Jones R, Hilsbos K, Storey E, Enright PL, Rao CY, Kreiss K. Respiratory morbidity in office workers in a water-damaged building. Environ Health Perspect 2005 Apr; 113(4):485-490.


Green BJ, Schmechel D, Sercombe JK, Tovey ER.Enumeration and detection of aerosolized Aspergillus fumigatus and Penicillium chrysogenum conidia and hyphae using a novel double immunostaining technique.J Immunol Methods 2005 Dec; 307(1-2):127-134.


Wells JR.Gas-phase chemistry of alpha-terpineol with ozone and OH radical: rate constants and products.Environ Sci Technol 2005 Sep; 39(18):6937-6943.


Schmechel D, Simpson JP, Beezhold,D, Lewis DM.The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. J Immunol Methods 2006 Feb; 309(1-2):150-159.


Donohue M,; Wei W, Wu J, Zawia NH, Hud N, Jesus VD, Schmechel D, Hettick JM, Beezhold DH; Vesper S.Characterization of nigerlysin, hemolysin produced by Aspergillus niger, and effect of mouse neuronal cells in vitro.Toxicology 2006 Feb; 219(1-3):150-155.


Weschler CJ, Wells, JR, Pearce T, Hubbard H, Poppendieck D.  Indoor Chemistry and Health: A Workshop Summary.  Environmental Health Perspectives, 114: 442-446, 2006.


Ham JE, Proper SP, Wells JR. Gas-Phase Chemistry of citronellol with Ozone and OH Radical: Rate Constants and Products. Atmospheric Environment, 40: 726-735, 2006.


Park JH, Cox-Ganser J, Rao C, KreissK. Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building.Indoor Air 2006 Jun; 16(3):192-203.


Surgeon General's Workshop on Healthy Indoor Environment, The workshop report and the opening remarks of Surgeon General Richard Carmona can be found at (External link)


September 19, 2005 Press Release Governor Rell Directs Agency Heads to Provide Definitive Recommendation on Future Use of 25 Sigourney Street. State of Connecticut Executive Chambers Hartford, CT


January 17, 2006 Press Release. Governor Rell Receives Report on 25 Sigourney Street Building; Report Finds Facility is Safe for Employees


Letters of support etc. Indoor air


Memorial Middle School HETA close out letter


Emails in support of indoor air ME-schools


Notice of Environmental Awards associated with indoor air work


The Team Document: Ten years of leadership advancing the National Occupational Research Agenda (NORA)


The RDRP-developed belt spirometer was loaned to state-based SENSOR asthma surveillance programs and academic occupational health researchers (e.g., at Duke University).


HETA # 2000-0401-2991 Gilster-Mary Lee Corp. Jasper, Missouri,


Balmes J, Becklake M, Blanc P, Henneberger P, Kreiss K, Mapp C, Milton D, Schwartz D, Toren K, Viegi G [2003]. American Thoracic Society Statement: Occupational contribution to the burden of airway disease. Am J Respir Crit Care Med 167:787-797


Attfield MD, Hodous TK. Pulmonary function of U.S. coal miners related to dust exposure estimates. Am Rev Respir Dis 1992;14:605-609). (ISI Web of Science


Attfield MD. Longitudinal decline in FEV1 in United States coalminers. Thorax 1985;40:132-137.


Hodgins P, Henneberger PK, Wang ML, Petsonk EL. Bronchial responsiveness and five-year FEV1 decline. Am J Respir Crit Care Med 1998;157:1390-1396.


Beeckman LF, Wang ML, Petsonk EL, Wagner GR. Rapid declines in FEV1 and subsequent respiratory symptoms, illnesses, and mortality in coal miners in the United States. Am J Respir Crit Care Med 2001;163:633-639.


Kuempel ED, Stayner LT, Attfield MD, Buncher CR. Exposure-response analysis of mortality among coal miners in the United States. Am J Ind Med 1995;28:167-184.


Vallyathan V, Green FHY, Brower P, Attfield M. The role of coal mine dust exposure in the development of pulmonary emphysema. Ann Occup Hyg 1997;41:352-357.


MSHA document: Secretary of Labor’s Advisory Committee on the Elimination of Pneumoconiosis Among Coal Mine Workers, published October 1996


List of 53 RDRP publications on COPD


NIOSH Safety and Health Topic: Occupational Respiratory Disease Surveillance


Section 10 of WoRLD report: COPD


Hnizdo E, Sullivan PA, Bang KM, Wagner G. Association between chronic obstructive pulmonary disease and employment by industry and occupation in the U.S. population: a study of data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2002; 156:738-746


Hnizdo E, Sullivan PA, Bang KM, Wagner G. Airflow obstruction attributable to work in industry and occupation among U.S. race/ethnic groups: A study of MHANES III data. Am J Ind Med 2004;46:126-135.


Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999;159:179-187.


Leigh JP, Romano PS, Schenker MB, Kreiss K. Costs of occupational COPD and asthma. Chest 2002; 121:264-272.


2005, a symposium was held on Wildland Firefighters to disseminate findings and to discuss with the Department of the Interior (DOI) the best ways to incorporate the findings into DOI policy


Work, Smoking, and Health. A NIOSH Scientific Workshop Proceedings. NIOSH, CDC, DHHS (NIOSH) Publication No. 2002-148


Wang ML, Gunel E, Petsonk EL. Design strategies for longitudinal spirometry studies: study duration and measurement frequency. Am J Respir Crit Care Med 2000;162:2134-2138.


Wang ML, Petsonk EL. Repeated Measures of FEV1 Over Six to Twelve Months: What Change is Abnormal. JOEM V46 No 6 June 2004. p591-595.


Hnizdo E, Yu L, Freyder L, Attfield M, Lefante J, Glindmeyer HW.The precision of longitudinal lung function measurements: monitoring and interpretation.Occup Environ Med 2005 Oct; 62(10):695-701.


Hnizdo E, Sircar K, Glindmeyer HW, Petsonk EL. Longitudinal limits of normal decline in lung function in an individual. J Occup Environ Med 2006;48:1-10.


Spirometry longitudinal data analysis (SPIROLA) - Topic Concept Memo


A workshop on “Interpretation of longitudinal spirometry data in an individual” - Topic Concept Memo


Flavoring Exposures and Worker Health in Microwave Popcorn Production, Workshop - NIOSH, November 2003.


NIOSH Alert: Preventing Lung Disease in Workers Who Use or Make Flavorings


Summary sheet from the Alert disseminated in Spanish (


Bronchiolitis Obliterans in New Occupational Settings: Developing a Clinical and Public Health Approach Saturday, August 25, 2001 (Workshop)


List of 14 RDRP articles from 2002-2006 related to popcorn and flavorings


Kanwal R, Kullman G, Piacitelli C, Boylstein R, Sahakian N, Martin S, Fedan K, Kreiss K [2006]. MDEvaluation of Flavorings-Related Lung Disease Risk at Six Microwave Popcorn Plants. JOEM 48:2.


Kreiss K, Gomaa A, Kullman G, et al. [2002]. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant.  N Engl J Med 347 (5):330-338.


Hubbs AF, Batelli LA, Goldsmith WT, et al. [2002].  Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol Appl Pharmacol 185:128-135.


J.S. Fedan, J.A. Dowdy, K.B. Fedan, A.F. Hubbs [2006]  Popcorn worker's lung: In vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine. Toxicology and Applied Pharmacology. 2006;215:17-22.


Letters of support etc. Spirometry