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NIOSH Respiratory Diseases Research Program

Evidence Package for the National Academies' Review 2006-2007

Appendix List - Chapter 3

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WoRLD Surveillance Report; Section 3 - Silica


Letter from Dr. Murray June 1, 2006


Hubbs AF, Minhas, NS, Jones W, Greskevitch M, Batteli L, Porter DW, Goldsmith WT, Frazer D, Landsittel DP, Ma JYC, Barger M, Hill K, Schwegler-Berry D, Robinson V, Castranova V. Comparative Pulmonary Toxicity of 6 Abrasive Blasting Agents. Toxicological Sciences 61, 135-143 (2001)


Porter D, Hubbs A, Robinson V, Battelli L, Greskevitch M, Barger M, Landsittel D, Jones W, Castranova V. Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agents. J Toxicol Environ Health, 2002 Aug 65(16):1121-1140


AF Hubbs, M Greskevitch, E Kuemple, F Suarez, M Toraason. Abrasive Blasting Agents:  Designing Studies to Evaluate Relative Risk. Proceedings for the 2004  Toxicology and Risk Assessment Conference.  J Toxicol Environ Health, Part A 68: 999-1016 (2005).


JE Craighead, J Kleinerman, JF Abraham, AR Gibbs, NV Vallyathan, and EB Juliano. Diseases associated with exposure to silica and non-fibrous silicate minerals.  Arch Pathol Lab  Med 112: 673-720, 1998.


MF Greskevitch, WD Corbett, MF Melampy, KA Trimber. Evaluation of  Substitute Materials for Silica Sand in Abrasive Blasting  Contract No. 200-95-2946 (Phase 1 – Laboratory Report).  NTIS Pub. No PB99-105553 (September, 1998).


MF Greskevitch, WD Corbett, MF Melampy, KA Trimber.Evaluation of Substitute Materials for Silica Sand in Abrasive Blasting Contract No. 200-95-2946 (Phase 2 – Field Study Report).  NTIS Pub. No. PB99-140964 (December, 21, 1998).


MF Greskevitch, WD Corbett, MF Melampy, KA Trimber. Evaluation of Substitute Materials for Silica Sand in Abrasive Blasting Contract No. 200-95-2946 (Phase 3 – Comparative Report).  NTIS Pub. No. PB99-140972. (April, 1999).


Communication of these results to industry, industrial hygienists, and governmental regulatory agencies is evidenced by 23 direct communications to partners


U.S. Geological Survey Minerals Yearbook - Dolley T [2004]. Silica sand usage


Letter from Mr. Perry June 1, 2006


Echt A, Sieber W, Jones E, Schill D, Lefkowitz D, Sugar J, Hoffner K [2003].  Case studies: Control of respirable dust and crystalline silica from breaking concrete with a jackhammer.  Appl. Occup. Environ Hyg. 18:491-495


Echt A, Sieber W, Jones A, Jones E [2002].  Case studies: Control of silica exposure in construction: scabbling concrete.  Appl. Occup. Environ. Hyg. 17:809-813.


Echt A, Sieber WK [2002].  Case studies: Control of silica exposures from hand tools in construction: grinding concrete.  Appl. Occup. Environ. Hyg. 17:457-461.] 


DW Porter, D Ramsey, AF Hubbs, L Battelli, J Ma, M Barger, D Landsetter, VA Robinson, J McLaurin, A Khan, W Jones, A  Teass, and V Castranova. Time course of pulmonary response of rats to inhalation ocrystalline silica: histological results and biochemical indices of damage, lipidosis and fibrosis.  J Environ Pathol Toxicol Oncol 20 (Suppl 2): 1-14, 2001.


Kuempel E, Tran Chi-Lang, Bailer JA, Porter DW, Hubbs A, Castranova V. Biological and Statistical Approaches to Predicting Human Lung Cancer Risk from Silica. Journal of Environmental Pathology, Toxicology and Oncology, 20 (Supple.1): 15-32 (2001) p15-32.


Green FHY, Althouse R, Weber K. Prevalence of Silicosis at Death in Underground Coal Miners. American Journ of Industrial Med. 16:605-165 (1989) p605-615.


Yucesoy B, Vallyathan V, Landsittel DP, Sharp DS, Weston A, Burleson GR, Simeonova P, McKinstry M, Luster MI. Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. Toxicol Appl Pharmacol 2001 Apr; 172(1):75-82.


Gulumian M, Borm PJA, Vallyathan V, Castranova V, Donaldson K, Nelson G, Murray J [2006]. Mechanistically identified suitable biomarkers of exposure, effect and susceptibility for silicosis: A comprehensive review. J Toxicol Environ Health Part B.9.


Letter from Mr. Perry, OSHA; June 1, 2006


The role of freshly fractured silica in acute silicosis. Columns-Silica in 2002


Peer input by RDRP used by OSHA’s Preliminary Health Effects Discussion on Silica


Letter from Dr. Donaldson June 1, 2006


Vallyathan V, Castranova V, Pack D, Leonard S, Shumaker J, Hubbs AF, Shoemaker DA, Ramsey DM, Pretty JR, McLaurin JL, Khan A, Teass A. Freshley Fractured Quartz Inhalation Leads to Enhanced Lung Injury and Inflammation. Potential Role of Free Radicals. Am J Respir Crit Care Med. Vol 152. pp1003-1009, 1995.


V Castranova, WH Pailes, NS Dalal, PR Miles, L Bowman, V Vallyathan, D Pack, KC Weber, AF Hubbs, D Schwegler-Berry, J Xiang, R Dey, J Blackford, JYC Ma, M Barger, DA Shoemaker, JR Pretty, DM Ramsey, JL  McLaurin, A Klan, PA Baron, CP Childress, LE Stettler, and AW Teass.  Enhanced pulmonary response to the inhalation of freshly fractured silica as compared to aged dust exposure.  Appl Occup Environ Hyg 11: 937-941, 1996.


Porter DW, Hubbs AF, Mercer R, Robinson V, Ramsey D, McLaurin J, Khan A, Battelli L, Brumbaugh K, Teass A, Castranova V. Progression of Lung Inflammation and Damage in Rats After Cessation of Silica Inhalation. Toxicological Sciences 79, 370-380 (2004).


Vallyathan V, Shi X, Dalal NS, Irr W, Castranova V. Generation of Free Radicals from Freshly Fractured Silica Dust. Potential Role in Acute Silica-Induced Lung Injury. Am Rev Respir Dis 1988 Nov;138(5):1213-1219.


Ding M, Shi X, Lu Y, Huang C, Leonard S, Roberts J, Antonini J, Castranova V, Vallyathan V.Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells. J Biol Chem 2001 Mar; 276(12):9108-9114.


Goodman GB, Kaplan PD, Stachura I, Castranova V, Pailes WH, Lapp NL. Acute Silicosis Responding to Corticosteroid Therapy. Chest 1992 Feb;101(2):366-370.


Gulumian M, Borm PJ, Vallyathan V, Castranova V, Donaldson K, Nelson G, Murray J.  [2006] Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review. J Toxicol Environ Health B Crit Rev; 9(5):357-395


NIOSH Brochure: Working with Cement Roofing Tiles: A silica hazard


Letter from Mr. Perry, June 1, 2006


DW Porter, SS Leonard, and V Castranova.  Particles and cellular oxidative and nitrosative stress.  In: The Toxicology of Particles. K Donaldson and P Borm (eds), 2006.


V Castranova.  Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure:  Role of reactive oxygen/nitrogen species.  Free Rad.  Biol. Med. 37:  916-925, 2004.


Shi X, Castranova V, Halliwell B, Vallyathan V. Reactive oxygen species and silica-induced carcinogenesis. J Toxicol Environ Health B 1998 Jul-Sep; 1(3):181-197.


Zeidler PC, Castranova V. Role of nitric oxide in pathological responses of the lung to exposure to environmental/occupational agents. Redox Rep 2004 Jan; 9(1):7-18.


Chemiluminescence. Eds. K Van Dyke and V. Castranova CRC Press, Boca Raton, 1987.2. Oxygen/Nitrogen Radicals: Cell Injury and Disease. Eds. V Vallyathan, X Shi, V Castranova. Kluwer Academic Publishers, Boston, 2002.3. Oxygen/Nitrogen Radicals: Lung Injury and Disease. Eds. V Vallyathan, V Castranova, X Shi. Marcel Dekker, New York, 2004 . 4.Silica and Silica-Induced Lung Diseases [1996]. Castranova V, Vallyathan V, Wallace WE eds. CRC Press, Boca Raton.


Nel A,  Xia T, Madler L, Li N [2006]. Toxic Potential of Materials at the Nanolevel. Science 311:622-627.


Peer review of Silica research sub-program: GPRA Results of a Pilot Evaluation of Biological Research


RDRP scientists served on EPA directed - International Life Sciences Institute (ILSI) international panel of 13 experts to develop a short-term screening strategy to evaluate fiber toxicity.  This panel noted the importance of free-radical generation in a screening strategy and cited RDRP’s work


RDRP scientists served on EPA directed - ILSI international panel of 14 experts to develop a screening in strategy for the toxicity of nanomaterials.  This panel also noted the importance of free-radical generation in a screening strategy. RDRP work was cited


Lentz T, MacMahon K, Zumwalde R, Doak C.NIOSH Doc 2006-123 Criteria for a recommended standard: occupational exposure to refractory ceramic fibers NIOSH 2006 May:1-203


Zumwalde, et al., NIOSH Interdivisional Fiber Subcommittee Final Report, March 17. 1999


Amandus HE, Wheeler R, Jankovic J, Tucker J.  The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part I.  Exposure estimates.  Am J Ind Med. 1987;11(1):1-14.  (ISI Web of Science: cited 24 times as of 7/18/06)


Amandus HE, Wheeler R.  The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part II. Mortality.  Am J Ind Med. 1987;11(1):15-26. (ISI Web of Science: cited 40 times as of 7/18/06)


Amandus HE, Althouse R, Morgan WK, Sargent EN, Jones R.  The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part III. Radiographic findings.  Am J Ind Med. 1987;11(1):27-37.


NIOSH Recommendations for Limiting Potential Exposures of Workers to Asbestos Associated with Vermiculite from Libby, Montana Fact Sheet


NIOSH research in Libby, MT: job-related asbestos exposures and health effects in mining and milling of vermiculite September 21, 2000


Vermiculite Facilities Site Evaluations Close-Out Letter HETA 2000-0407, 2004;


NIOSH Comments to MSHA Advance Notice of Proposed Rulemaking


NIOSH Comments on MSHA Proposed Rule


NIOSH testimony at MSHA hearing on rulemaking


Castellan RM, Sanderson WT, Petersen MR.  Prevalence of radiographic appearance of pneumoconiosis in an unexposed blue collar population. Am Rev Respir Dis. 1985:131:684-686.


World Surveillance Report  2002 Section 1, Asbestosis


ATSDR’s National Asbestos Exposure Review

A3-99 Part 1
A3-99 Part 2
A3-99 Part 3
A3-99 Part 4

The resulting “Report on the Expert Panel on Health Effects of Asbestos and Synthetic Vitreous Fibers: The Influence of Fiber Length” (Prepared for: Agency for Toxic Substances and Disease Registry, March 17, 2003)


Proposed rule for reduction of MSHA PEL for asbestos (Federal Register, July 29, 2005)


Centers for Disease Control.  Chronic interstitial lung disease in nylon flocking industry workers--Rhode Island, 1992-1996.  MMWR 1997;46:897-901.


Burkhart J, Piacitelli C, Schwegler-Berry D, Jones W.  Environmental study of nylon flocking process.  J Toxicol Environ Health. 1999;57(Part A):1-23.


Porter DW, Castranova V, Robinson VA, Hubbs AF, Mercer RR, Scabilloni J, Goldsmith T, Schwegler-Berry D, Battelli L, Washko R, Burkhart J, Piacitelli C, Whitmer M, Jones W.  Acute inflammatory reaction in rats after intratracheal instillation of material collected from a nylon flocking plant.  J Toxicol Environ Health. 1999;57(Part B):25-45.


Washko RM, Day B, Parker JE, Castellan RM, Kreiss K.  Epidemiologic investigation of respiratory morbidity at a nylon flock plant.  Am J Ind Med 2000;38:628-638.


Daroowalla F, Wang ML, Piacitelli C, Attfield MD, Kreiss K. Flock workers' exposures and respiratory symptoms in five plants. Am J Ind Med. 2005 Feb;47:144-52. 


Eschenbacher WL, Kreiss K, Lougheed D, Pransky G, Day B, Castellan RM.  Nylon flock-associated interstitial lung disease: clinical pathology workshop summary.  Am J Respir Crit Care Med 1999;159:2003-2008.


Boag AH, Colby TV, Fraire AE, Kuhn C III, Roggli VL, Travis WD, Vallyathan V. The pathology of interstitial lung disease in nylon flock workers.  Am J Surg Pathol 1999;23:1539-1545.


Dunn KH, ShulmanSA, Cecala AB, Venturin DE. Evaluation of a local exhaust ventilation system for controlling refractory ceramic fibers during disc sanding. J Occup Environ Hyg 2004 Oct; 1(10):D107-D111.


Simeonova PP, Toriumi W, Kommineni C, Erkan M, Munson AE, Rom WN, Luster MI. Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: role of reactive oxygen species. J Immunol 1997 Oct; 159(8):3921-3928.


Deye GJ, Gao P, Baron PA, Fernback J.  Performance of a fiber length classifier.  Aerosol Sci Technol. 1999;30(5): 420-437.


Blake T, Castranova V, Schwegler-Berry D, Baron P, Deye GJ, Li C, Jones W. Effect of fiber length on glass microfiber cytotoxicity. J Toxicol Environ Health 1998;54:243-259.


Ye JP, Shi XL, Jones W, Rojanasakul Y, Cheng NL, Schwegler-Berry D, Baron P, Deye GJ, Li CH, Castranova V.  Critical role of glass fiber length in TNF-alpha production and transcription factor activation in macrophages.  Am J Physiol-Lung Cell Molec Physiol. 1999;276: L426-L434.


Ye J, Zeidler PC, Young S, Martinez AB, Robinson VA, Jones W, Baron P, Shi X, Castranova V. Activation of mitogen-activated protein kinase p38 and extracellular signal-regulated kinase is involved in glass fiber-induced tumor necrosis factor-alpha production in macrophages. J Biol Chem 2001 Feb; 276(7):5360-5367.


Zeidler-Erdely PC, Calhoun WJ, Ameredes BT, Clark MP, Deye GJ, Jones WJ, Blake T, Castranova V.  In vitro cytotoxicity of Manville Code 100 glass fibers: Effect of fiber length on human alveolar macrophages.  Part Fibre Toxicol.  2006;3:5.


Bernstein D, Castranova V, Donaldson K, Fubini B, Hadley J, Hesterberg T, Kane A, Lai D, McConnell EE, Muhle H, Oberdorster G, Olin S, Warheit DB; ILSI Risk Science Institute Working Group. Testing of fibrous particles: short-term assays and strategies. Inhal Toxicol 2005;17:497-537.


List of 41 RDRP publications on chronic beryllium disease


Schuler CR, Kent MS, Deubner DC, Berakis MT, McCawley M, Henneberger PK, Rossman MD, Kreiss K. Process-related risk of beryllium sensitization and disease in a copper-beryllium alloy facility. Am J Ind Med 2005 Mar; 47(3):195-205.


Cummings KJ, Deubner DC, Day GA, Henneberger PK, Kitt MM, Kent M, Kreiss K, Schuler CR. Enhanced preventive program at a beryllium oxide ceramics facility reduces beryllium sensitisation among new workers. Occupational and Env. Med. 2006, submitted.


Stefaniak AB, Hoover MD, Dickerson RM, Peterson EJ, Day GA, Breysse PN, Kent MS, Scripsick RC. Surface area of respirable beryllium metal, oxide, and copper alloy aerosols and implications for assessment of exposure risk of chronic beryllium disease. American Industrial Hygiene Association Journal 2003; 64:297-305.


Stefaniak AB, Hoover MD, Day GA, Dickerson RM, Peterson EJ, Kent MS, Schuler CR, Breysse PN, Scripsick RC. Characterization of physicochemical properties of beryllium aerosols associated with chronic beryllium disease. J. Env. Monitoring 6:523-532, 2004.


McCawley MA, Kent MS, Berakis M.Ultrafine beryllium number concentration as a possible metric for chronic beryllium disease risk. Appl Occup Environ Hyg 2001 May; 16(5):631-638.


Agrawal A, Cronin J, Tonazzi J, McCleskey TM, Ehler DS, Minogue EM, Whitney G, Brink C, Burrell AK, Warner B, Goldcamp MJ, Schlecht PC, Sonthalia P, Ashley K. Validation of a standardized portable fluorescence method for determining trace beryllium in workplace air and wipe samples. Journal of Environmental Monitoring 2006; DOI: 10.1039/b601524g.


Snyder JA, Weston A, Tinkle SS, Demchuk-E.Electrostatic potential on human leukocyte antigen: implications for putative mechanism of chronic beryllium disease. Environ Health Perspect 2003 Nov; 111(15):1827-1834.


RDRP news-letter: NIOSH Beryllium Research Highlights, issued in July 2005


RDRP news-letter: NIOSH Beryllium Research Highlights, issued in June 2003


Letters of Support etc. Coal


Letters of Support etc. Silica


Letters of Support etc. Beryllium