International Chemical Safety Cards NICOTINAMIDE ICSC: 1703 Pyridine-3-carboxylamide 3-Pyridinecarboxamide Niacinamide C6H6N2O Molecular mass: 122.1 ICSC #    1703 CAS #     98-92-0 RTECS # QS3675000 April 08, 2008 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Water spray, foam, powder, carbon dioxide. EXPLOSION Finely dispersed particles form explosive mixtures in air. Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION Cough. Avoid inhalation of dust. Fresh air, rest.  •SKIN Protective gloves. Rinse skin with plenty of water or shower.  •EYES Redness. Pain. Safety goggles Rinse with plenty of water (remove contact lenses if easily possible).  •INGESTION Do not eat, drink, or smoke during work. Rinse mouth. Give one or two glasses of water to drink. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Personal protection: particulate filter adapted to the airborne concentration of the substance. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Separated from oxidants. Signal: Warning Causes eye irritation SEE IMPORTANT INFORMATION ON BACK ICSC: 1703 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards NICOTINAMIDE ICSC: 1703 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE CRYSTALLINE POWDER. PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air. CHEMICAL DANGERS: On combustion, forms toxic gases, including nitrogen oxides. Reacts with oxidants. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK not established. ROUTES OF EXPOSURE: INHALATION RISK: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Sublimation Melting point: 127-131°C Density: 1.4 g/cm³ Solubility in water, g/100 ml at 20°C: 100 (very good) Vapour pressure, kPa at 35°C: 3.1 Relative vapour density (air = 1): 4.2 Flash point: 182°C Auto-ignition temperature: 480°C Octanol/water partition coefficient as log Pow: -0.38 ENVIRONMENTAL DATA N O T E S ADDITIONAL INFORMATION ICSC: 1703 NICOTINAMIDE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.