International Chemical Safety Cards DIPHENYLETHER, OCTABROMO DERIVATIVE ICSC: 1667 Octabromodiphenyl Ether 1,1'-Oxybisoctabromo benzene Octabromodiphenyl oxide C12H2Br8O/C6HBr4OC6HBr4 Molecular mass: 801.38 ICSC #    1667 CAS #     32536-52-0 RTECS # DA6626666 November 11, 2008 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION EXPOSURE AVOID EXPOSURE OF BREASTFEEDING WOMEN!  •INHALATION Cough. Avoid inhalation of dust Ventilation. Fresh air, rest.  •SKIN Protective gloves. Rinse and then wash skin with water and soap.  •EYES Safety spectacles. Rinse with plenty of water (remove contact lenses if easily possible).  •INGESTION Do not eat, drink, or smoke during work. Rinse mouth. Give one or two glasses of water to drink. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Personal protection: particulate filter adapted to the airborne concentration of the substance. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Separated from food and feedstuffs T symbol R: 61-62 S: 53-45 Signal: Warning Health haz Suspected of damaging fertility or the unborn child May cause harm to breast-fed children SEE IMPORTANT INFORMATION ON BACK ICSC: 1667 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards DIPHENYLETHER, OCTABROMO DERIVATIVE ICSC: 1667 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE FLAKES or POWDER PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating, producing corrosive gases OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: A nuisance-causing concentration of airborne particles can be reached quickly. EFFECTS OF SHORT-TERM EXPOSURE: EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Animal tests show that this substance possibly causes toxicity to human reproduction or development. The substance may have effects on the liver. TE & SUBCHRONIC: These studies consistently indicate that the liver is the key target organ affected by OBDPO.The effects observed include increases in liver weight and liver enlargement, cellular microscopic changes, scattered incidence of hyperplastic nodules during the withdrawal period (8 weeks and 6 months) and induction of a range of liver enzymes. Following oral administration, thyroid gland effects are observed including increases in thyroid weight and histopathological changes suggesting an increase in thyroid gland stimulation, depletion of T4, decrease of serum T3, increased TSH level via an inductionof the hepatic enzymes. alterations in thyroid homeostasis by organochlorine compounds have been documented for many species, including humans. PHYSICAL PROPERTIES Melting point: 167-257°C (See Notes) Relative density (water = 1): 2.9 Solubility in water: (very poor) Vapour pressure, Pa at °C: negligible Octanol/water partition coefficient as log Pow: 6.29 ENVIRONMENTAL DATA Environmental effects from the substance have not been investigated adequately. N O T E S Other melting points: 130-155°C; 70-150°C and 167-257°C. The substance has a variable melting and boiling range, reflecting the nature of the material and the individual manufacturing processes. ADDITIONAL INFORMATION ICSC: 1667 DIPHENYLETHER, OCTABROMO DERIVATIVE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.