International Chemical Safety Cards METHOXYFLURANE ICSC: 1636 2,2-Dichloro-1,1-difluoroethyl methyl ether 2,2-Dichloro-1,1-difluoro-1-methoxyethane Methoflurane Penthrane C3H4Cl2F2O / CH3OCF2CHCl2 Molecular mass: 165.0 ICSC #    1636 CAS #     76-38-0 RTECS # KN7820000 April 04, 2006 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION Above 63°C explosive vapour/air mixtures may be formed. Above 63°C use a closed system, ventilation. EXPOSURE  •INHALATION Dizziness. Drowsiness. Unconsciousness. Ventilation, local exhaust, or breathing protection. Fresh air, rest.  •SKIN Protective gloves. Rinse skin with plenty of water or shower.  •EYES Redness. Safety spectacles or eye protection in combination with breathing protection. . First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Personal protection: filter respirator for organic gases and vapours. Collect leaking liquid in sealable metal containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Signal: Warning Health haz Combustible liquid May cause damage to kidneys if inhaled SEE IMPORTANT INFORMATION ON BACK ICSC: 1636 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards METHOXYFLURANE ICSC: 1636 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning, producing toxic fumes hydrogen chloride, hydrogen fluoride ). Attacks some forms of plastic and rubber . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: Exposure at high levels may result in unconsciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the kidneys , resulting in kidney impairment . PHYSICAL PROPERTIES Boiling point: 105°C Melting point: -35°C Relative density (water = 1): 1.42 Solubility in water, g/100 ml at 37°C: 2.83 (poor) Vapour pressure, kPa at 20°C: 3.1 Relative vapour density (air = 1): 5.7 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.1 Flash point: 63°C Explosive limits, vol% in air: 7-? Octanol/water partition coefficient as log Pow: 2.21 ENVIRONMENTAL DATA N O T E S ADDITIONAL INFORMATION ICSC: 1636 METHOXYFLURANE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.