International Chemical Safety Cards PYRETHRUM ICSC: 1475 Buhach Pyrethrum extract Pyrethrum oleoresin ICSC #    1475 CAS #     8003-34-7 RTECS # UR4200000 EC #         613-022-00-6 November 25, 2003 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. NO contact with oxidants. Powder, water spray, foam, carbon dioxide. EXPLOSION Risk of fire and explosion on contact with oxidants. EXPOSURE PREVENT GENERATION OF MISTS!  •INHALATION Headache. Nausea. Vomiting. Ventilation (not if powder), local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Redness. Pain. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Redness. Pain. Safety goggles or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Numbness of tongue and lips. Excitation. Convulsions. Tetanic paralysis. Muscular fibrillation. Death from respiratory failure. Do not eat, drink, or smoke during work. Wash hands before eating. Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: A/P2 filter respirator for organic vapour and harmful dust. Separated from strong oxidants, food and feedstuffs . Well closed. Provision to contain effluent from fire extinguishing. Do not transport with food and feedstuffs. Xn symbol N symbol R: 20/21/22-50/53 S: 2-13-60-61 SEE IMPORTANT INFORMATION ON BACK ICSC: 1475 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards PYRETHRUM ICSC: 1475 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: PALE YELLOW MOBILE OIL , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing smoke and irritating fumes . Reacts with strong oxidants causing fire and explosion hazard. OCCUPATIONAL EXPOSURE LIMITS: TLV: 5 mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2008). MAK: IIb (not established but data is available); sensitization of skin (Sh); (DFG 2008). OSHA PEL: TWA 5 mg/m3 NIOSH REL: TWA 5 mg/m3 NIOSH IDLH: 5000 mg/m3 See: 8003347 ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the nervous system . EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. PHYSICAL PROPERTIES Decomposes below boiling point 170 °C at 0.01 kPa Density: 0.84-0.86 g/cm³ Solubility in water: none Flash point: 76°C c.c. Octanol/water partition coefficient as log Pow: 4.3 (pyrethrin I); 5.9 (pyrethrin II) ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to honey bees. N O T E S Pyrethrum is a mixture of pyrethrin I and II, cinerin I and II, and jasmolin I and II. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. Card has been partially updated in February 2009: see Occupational Exposure Limits. ADDITIONAL INFORMATION ICSC: 1475 PYRETHRUM (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.