International Chemical Safety Cards

DISULFIRAM ICSC: 1438
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
Tetraethylthiuramdisulfide
1,1'-Dithiobis(N,N-diethylthioformamide)
bis-(N,N-Diethylthiocarbamoyl)disulfide
TETD
C10H20N2S4 / ((C2H5)2NCS)2S2
Molecular mass: 269.6
ICSC #    1438
CAS #     97-77-8
RTECS # JO1225000
EC #         006-079-00-8
September 10, 2002 Validated
L, October 2001 (not reviewed); postponed in Montreal 2002 for biological references.
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding).

EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!

 •INHALATION
Ventilation, local exhaust, or breathing protection.

 •SKIN
Protective gloves.
Rinse skin with plenty of water or shower.
 •EYES
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION Confusion. Headache. Nausea. Vomiting.
Do not eat, drink, or smoke during work.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.
Separated from strong oxidants.

Xn symbol
N symbol
R: 22-43-48/22-50/53
S: 2-24-37-60-61
SEE IMPORTANT INFORMATION ON BACK
ICSC: 1438 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

DISULFIRAM ICSC: 1438
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PHYSICAL STATE; APPEARANCE:
WHITE TO GREY POWDER , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic and corrosive fumes including nitrogen oxides , sulfur oxides . Reacts violently with strong oxidants. Attacks copper.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 mg/m as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: (Inhalable fraction) 2 mg/m; sensitization of skin (Sh);
Peak limitation category: II(8); Pregnancy risk group: D;
(DFG 2004).
OSHA PEL: none
NIOSH REL: TWA 2 mg/m3 Precautions should be taken to avoid concurrent exposure to ethylene dibromide.
NIOSH IDLH: N.D. See: IDLH INDEX


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of dust and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:


EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the endocrine system , liver , nervous system and thyroid , resulting in impaired functions . Animal tests show that this substance possibly causes toxicity to human reproduction or development.
PHYSICAL
PROPERTIES
Boiling point at 2.3kPa: 117C
Melting point: 71C
Density: 1.3
g/cm
Solubility in water, g/100 ml: 0.02
Octanol/water partition coefficient as log Pow: 3.9
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is toxic to aquatic organisms.
N O T E S
In combination with alcohol the substance causes effects on cardiovascular and central nervous systems resulting in palpitation, hypotension and hyperventilation. The effects may be delayed. Do NOT take working clothes home. Antabuse and Rosulfiram are trade names. Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


ICSC: 1438 DISULFIRAM
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.