International Chemical Safety Cards ISOFLURANE ICSC: 1435 Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane C3H2ClF5O Molecular mass: 184.5 ICSC #    1435 CAS #     26675-46-7 RTECS # KN6799000 May 03, 2002 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION EXPOSURE  •INHALATION Cough. Sore throat. Dizziness. Drowsiness. Headache. Unconsciousness. See Notes. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Redness. Dry skin. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Redness. Pain. Safety spectacles or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Ventilation. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: self-contained breathing apparatus. Ventilation along the floor. SEE IMPORTANT INFORMATION ON BACK ICSC: 1435 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ISOFLURANE ICSC: 1435 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS LIQUID PHYSICAL DANGERS: The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen. CHEMICAL DANGERS: On contact with hot surfaces or flames this substance decomposes forming corrosive fumes including phosgene , hydrogen chloride and hydrogen fluoride OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK: IIb (not established but data is available) (DFG 2008). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes and the skin . The vapour is irritating to the respiratory tract . The substance may cause effects on the central nervous system and cardiovascular system . Exposure at high levels may result in unconsciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 48.5°C Relative density (water = 1): 1.5 Solubility in water: poor Vapour pressure, kPa at 20°C: 32 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.2 Octanol/water partition coefficient as log Pow: 2.1 ENVIRONMENTAL DATA N O T E S Check oxygen content before entering area. High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death. Forane is a trade name. Card has been partly updated in April 2005. See sections Physical properties, Occupational Exposure Limits. ADDITIONAL INFORMATION ICSC: 1435 ISOFLURANE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.