International Chemical Safety Cards

EPN ICSC: 0753
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
Phosphonothioic acid, phenyl-, O-ethyl O-(4-nitrophenyl) ester
O-Ethyl O-4-nitrophenyl phenyl phosphonothioate
C14H14NO4PS
Molecular mass: 323.3
6 Poison placard Marine Pollutant placard ICSC #    0753
CAS #     2104-64-5
RTECS # TB1925000
UN #        2783
EC #         015-036-00-2
November 11, 2008 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Dizziness. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Muscle twitching. 0,33; ds; 3; 00 sequence (NOT on card): 17125, 17143, 17129, 17142, 17127, 17131, 17119, 17114, 17137;
Local exhaust or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
 •SKIN MAY BE ABSORBED! Redness. Pain. (Further See Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid. Put clothes in sealable container (SEE Notes). soluble in water; tion; 0 skn-rat:25 mg/kg (ref.11);
 •EYES Redness. Blurred vision.
Face shield, or eye protection in combination with breathing protection if powder. Safety spectacles
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
 •INGESTION Nausea. Abdominal cramps. Vomiting. Diarrhoea. Drowsiness. (Further see Inhalation). dy diarrhea),25,26,30; sness (ref.30); eathing. an (ref.5,21) onstriction, muscle cramps, excessive salivation.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. , bioacumulation used
Separated from strong oxidants,food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. to aquatic organisms; 45
Do not transport with food and feedstuffs.
Severe marine pollutant.
T+ symbol
N symbol
R: 27/28-50/53
S: 1/2-22-36/37-45-60-61
UN Hazard Class: 6.1
UN Packing Group: I
Signal: Danger
Skull-Health haz-Enviro
Fatal if swallowed
Fatal if inhaled
Fatal in contact with skin
Causes damage to the nervous system
Very toxic to aquatic life with long-lasting effects
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0753 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

EPN ICSC: 0753
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PHYSICAL STATE; APPEARANCE:
LIGHT YELLOW CRYSTALLINE POWDER , WITH CHARACTERISTIC ODOUR. dour (ref. 11,26);

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating producing toxic and corrosive fumes including , nitrogen oxides , phosphorus oxides sulfur oxides. Reacts with strong oxidants causing fire and explosion hazard. The substance decomposes under the influence of bases producing p-nitrophenol (see ICSC 0066). 1,26;

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.1 mg/m as TWA
(Inhalable fraction;)
(skin); BEI issued; A4 (not classifiable as a human carcinogen); (ACGIH 2008).
MAK: 0.05 mg/m (Inhalable fraction);
Pregnancy risk group: D; Peak limitation category: II(2);
skin absorption (H); (DFG 2008).

percutaneous absorption
OSHA PEL: TWA 0.5 mg/m3 skin
NIOSH REL: TWA 0.5 mg/m3 skin
NIOSH IDLH: 5 mg/m3 See: 2104645


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. kin: 25 mg/kg (ref.11); 25-230 mg/kg (ref.5, 13); at oral: 7.7 mg/kg; 36 mg/kg (ref.11,13), 14.5-91 mg/kg (ref.5);

INHALATION RISK:
A harmful concentration of airborne particles can be reached quickly.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes and the skin. Cholinesterase inhibitor. The substance may cause effects on the nervous system , resulting in convulsions, respiratory failure. Exposure may result in unconsciousness or death. The effects may be delayed. Medical observation is indicated. burns),28,39; ; (oral lethal dose in humans: 0.3 gramsr (70 kg) (ref. 30).;

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.
PHYSICAL
PROPERTIES
Boiling point at 0.667 kPa: 215C
Melting point: 36C
Density: 1.3 g/cm
Solubility in water: none
Vapour pressure, Pa at 25C: < 0.01
Octanol/water partition coefficient as log Pow: 4.78
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal. g Kow:4.48 (ref.26,24), BCF: 358-7,700 in fish, moderate bioconc., non-bidegrad. (ref.42); nce may be hazardous to the environment; special attention should be given to honey bees, birds. (ref.39);
N O T E S
Depending on the degree of exposure, periodic medical examination is indicated. Isolate contaminated clothing by sealing in a bag or other container. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-61GT7
ADDITIONAL INFORMATION


ICSC: 0753 EPN
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.