International Chemical Safety Cards 1,3-DINITROBENZENE ICSC: 0691 1,3-Dinitrobenzol m-Dinitrobenzene 1,3-DNB C6H4N2O4 / C6H4(NO2)2 Molecular mass: 168.1 ICSC #    0691 CAS #     99-65-0 RTECS # CZ7350000 UN #        3443 EC #         609-004-00-2 May 03, 2002 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Water spray, foam, powder, carbon dioxide. EXPLOSION Finely dispersed particles form explosive mixtures in air. Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Burning sensation. Blue lips or finger nails. Blue skin. Dizziness. Headache. Nausea. Weakness. Laboured breathing. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN MAY BE ABSORBED! (See Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Consult an expert! Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus. Separated from strong oxidants, strong bases, food and feedstuffs. See Chemical Dangers. Do not transport with food and feedstuffs. Note: C T+ symbol N symbol R: 26/27/28-33-50/53 S: 1/2-28-36/37-45-60-61 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0691 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 1,3-DINITROBENZENE ICSC: 0691 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: YELLOW CRYSTALS PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air. CHEMICAL DANGERS: May explode on heating, even in absence of air. On combustion, forms toxic gases and fumes including nitrogen oxides. Reacts violently with strong oxidants, strong bases, and reducing metals (tin and zinc), causing fire and explosion hazard. Attacks some plastic and rubber. OCCUPATIONAL EXPOSURE LIMITS: OSHA PEL: TWA 1 mg/m3 skin NIOSH REL: TWA 1 mg/m3 skin NIOSH IDLH: 50 mg/m3 See: IDLH INDEX TLV: 0.15 ppm as TWA; (skin); BEI issued; (ACGIH 2004). MAK: skin absorption (H); Carcinogen category: 3B; (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes and the respiratory tract . The substance may cause effects on the blood , resulting in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the blood , resulting in anaemia . The substance may have effects on the liver , resulting in liver impairment. The substance may have effects on the nervous system and may cause impaired vision. Animal tests show that this substance possibly causes toxicity to human reproduction or development. PHYSICAL PROPERTIES Boiling point: 300-303°C Melting point: 90°C Density: 1.6 g/cm³ Solubility in water: very poor Vapour pressure, kPa at 20°C: <0.1 Relative vapour density (air = 1): 5.8 Flash point: 149°C Octanol/water partition coefficient as log Pow: 1.49 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. N O T E S Use of alcoholic beverages enhances the harmful effect. Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. See ICSC 0460 (1,2-Dinitrobenzene), 0692 (1,4-Dinitrobenzene), 0725 (Dinitrobenzene, mixed isomers). Card has been partly updated in April 2005. See section Occupational Exposure Limits. Transport Emergency Card: TEC (R)-61S3443-S NFPA Code: H3; F1; R4; for 1,2-Dinitrobenzene. ADDITIONAL INFORMATION ICSC: 0691 1,3-DINITROBENZENE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.